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A mouse study found that the drug ketamine can alter the brain's dopamine system, boosting the case for more targeted medical use.

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Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.

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An international team of researchers has elucidated the process by which the major flavonoids naringenin, apigenin, and genistein are metabolized in the body. These findings are fundamental in elucidating the correlation between the metabolism of flavonoids in the body and their potential health benefits.

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New research has revealed a previously unknown process through which pathogens are able to defeat a cell's defense mechanisms with physical force. The discovery represents a potential game-changer in the fight against intracellular pathogens, which cause infectious diseases such as tuberculosis, malaria and chlamydia.

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Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal centers (GCs) are the centerpiece. Despite the apparent absence of GCs or similar SLMs in cold-blooded vertebrates (e.g., fish), these species can mount significant antibody responses that can persist for several months. Thus, for decades, the outstanding question has remained as to how and where antibody responses are generated in species that lack GCs or analogous SLM structures.

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In a step toward more autonomous soft robots and wearable technologies, researchers have created a device that uses color to simultaneously sense multiple mechanical and temperature stimuli.

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Astronomers studying images from the James Webb Space Telescope have identified an object as a 'dusty star-forming galaxy' from nearly 1 billion years after the Big Bang. They have also discovered more than a dozen additional candidates, suggesting these galaxies might be three to 10 times as common as expected. If that conclusion is confirmed, it suggests the early universe was much dustier than previously thought.

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Some nonnative plants cultivated in public gardens or arboretums are escaping to become invasive in wild forests.

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Societies and political structures, like the humans they serve, appear to become more fragile as they age, according to an analysis of hundreds of pre-modern societies. A new study, which holds implications for the modern world, provides the first quantitative support for the theory that the resilience of political states decreases over time. 

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Children must be taught more about the importance of plants if education about climate change and sustainability is to be effective, experts have warned.

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How do you create strong, yet quick-release connections between living and non-living tissues? This is a question that continues to puzzle bioengineers who aim to create materials that bond together for advanced biomedical applications. Looking to nature for inspiration, this research zeroed in on the marine mussel byssus, a fibrous holdfast, which these bivalve mollusks use to anchor themselves in seashore habitats.

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A simple-to-apply, needle-free vaccine patch is being developed to protect people from the potentially deadly mosquito-borne Zika virus.

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Researchers give medieval Cambridge residents the 'Richard III treatment' to reveal hard-knock lives of those in the city during its famous university's early years. Study of over 400 remains from a hospital cemetery shows spectrum of medieval poverty, and suggests that some of Cambridge University's earliest scholars ended up in penury.   

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An international multidisciplinary team consisting of solar physicists, geophysicists, and historians from nine countries analysed observations of an extreme solar-terrestrial storm reported in historical records from February 1872. Their findings confirm that a moderate sunspot group triggered one of the largest magnetic storms ever recorded, almost covering the entire night sky with colourful aurorae in both hemispheres. If such an extreme storm occurred today, it would severely disrupt modern technological infrastructure. Their study emphasizes the importance of looking at historical records in light of modern scientific knowledge.

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A team of scientists has emphasized that -- surprisingly -- there is currently no formally agreed way of defining the current level of global warming relevant to the Paris Agreement.

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A new semiconductor architecture integrates traditional electronics with photonic, or light, components could have application in advanced radar, satellites, wireless networks and 6G telecommunications. And it provides a pathway for a local semiconductor industry.

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Micrometeorites originating from icy celestial bodies in the outer Solar System may be responsible for transporting nitrogen to the near-Earth region in the early days of our solar system.

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Research suggests that Paleolithic humans in the Middle East selected flint for their cutting tools based on differences in the mechanical properties of the rock. They seem to have purposefully selected the most suitable rocks for fashioning into tools, even being able to distinguish rocks that were unsuitable.

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Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.

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A team presents a groundbreaking advance for the world of high-resolution fluorescence microscopy: The innovative method enables researchers for the first time to use biomolecules as molecular rulers to calibrate the latest super-resolution microscopy methods, which have a resolution of just a few nanometers.