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Categories: Chemistry: Biochemistry

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Simulations on the Stampede2 supercomputer of the Texas Advanced Computing Center (TACC) are helping scientists engineer solutions to overheating of grid transformers -- a critical component of the electric grid.

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Researchers adapt a novel force measurement technique to uncover the previously unidentified physics at play at the thin air-film gap between water droplets and superhydrophobic surfaces.

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Researchers found that a new activator called L687 induces cancer cells to accept delivery of antisense oligonucleotide (ASO) drugs. These drugs can treat cancer by blocking the transfer of messages from genes that encourage cancer growth. Previous methods to deliver ASOs into cells had only limited success. This research will help accelerate the development and delivery of novel ASO cancer therapies.

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4.5 million gamers around the world have advanced medical science by helping to reconstruct microbial evolutionary histories using a minigame included inside the critically and commercially successful video game, Borderlands 3. Their playing has led to a significantly refined estimate of the relationships of microbes in the human gut. The results of this collaboration will both substantially advance our knowledge of the microbiome and improve on the AI programs that will be used to carry out this work in future.

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Researchers analyzed the effects of solvation and ion valency on metallopolymers, with implications for critical materials recovery and recycling, and environmental remediation.

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The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.

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While there's no regulation in the U.S. for what's in organic shampoos, they tend to contain ingredients perceived as safe or environmentally friendly. However, these 'clean' shampoos separate and spoil faster than those made with synthetic stabilizers and preservatives. Now, researchers demonstrate that a simple process -- spinning organic shampoo at high speeds -- improved the final products' shelf lives and ability to clean hair.

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Tyche is a machine-learning framework that can generate plausible answers when asked to identify potential disease in medical images. By capturing the ambiguity in images, the technique could prevent clinicians from missing crucial information that could inform diagnoses.

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Cloud 'engineering' could be more effective for climate cooling than previously thought, because of the increased cloud cover produced, new research shows.

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Researchers have developed synthetic platelets that can be used to stop bleeding and enhance healing at the site of an injury. The researchers have demonstrated that the synthetic platelets work well in animal models but have not yet begun clinical trials in humans.

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Researchers have developed a novel method of adding polyethylene glycol molecules to engineered groups of messenger RNAs called 'mRNA polyplexes', which enable the cells that receive them to produce specific proteins. This technique allows greater control of the site in the body to which the polyplexes are delivered, significantly advancing the field of therapeutic mRNA technologies, with applications in vaccine development and the treatment of cancer and other diseases.

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Chemists show that a machine-based method prevents widespread 'bias' in chemical publications.

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In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

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Wirelessly connected devices perform an expanding array of applications, such as monitoring the condition of machinery and remote sensing in agricultural settings. These applications hold much potential for improving the efficiency, but how do you power these devices where reliable electrical sources are not available? Research points to a possible solution in the form of a novel type of battery.

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A study that could help revolutionize wireless communication introduces a novel method to curve terahertz signals around an obstacle.

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Scientists are using computer simulations and laboratory experiments to see if depleted oil and natural gas reservoirs can be used for storing carbon-free hydrogen fuel. Hydrogen is an important clean fuel: It can be made by splitting water using solar or wind power, it can be used to generate electricity and power heavy industry, and it could be used to power fuel-cell-based vehicles. Additionally, hydrogen could be stored for months and used when energy needs outpace the supply delivered by renewable energy sources.

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Researchers unveiled BeatProfiler, a groundbreaking new tool -- a comprehensive software that automates the analysis of heart cell function from video data. It's the first system to integrate the analysis of different heart function indicators, such as contractility, calcium handling, and force output into one tool, speeding up the process significantly and reducing the chance for errors. BeatProfiler enabled the researchers to not only distinguish between different diseases and levels of their severity but also to rapidly and objectively test drugs that affect heart function.

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A new molecular test method helps to prove the authenticity of works of art. The new method could also help to make passwords secure against quantum computers.

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Did you know that the world's deadliest animal is the mosquito? And Aedes aegypti is one of the most dangerous. This bug spreads viruses that cause dengue fever, which was recently declared as an epidemic in Puerto Rico. Research reports new molecules that label proteins in the unique, alkaline environment of the Ae. aegypti digestive system that could help scientists develop insecticides to fight back.

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Scientists have developed an automated workflow that could accelerate the discovery of new pharmaceutical drugs and other useful products. The new automated approach could analyze chemical reactions in real time and identify new chemical-reaction products much faster than current laboratory methods.