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Categories: Biology: Microbiology, Space: Exploration

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Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.

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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation.  Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.

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Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.

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The internal clocks of grizzly bears appear to keep ticking through hibernation, according to a genetic study. This persistence highlights the strong role of circadian rhythms in the metabolism of many organisms including humans. The genetic study confirmed observational evidence that bears' energy production still waxes and wanes in a daily pattern even as they slumber for several months without eating. The researchers also found that during hibernation the amplitude of the energy production was blunted, meaning the range of highs and lows was reduced. The peak also occurred later in the day under hibernation than during the active season, but the daily fluctuation was still there. 

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Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.

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Many mammals, from domestic cats and dogs to giant pandas, use scent to communicate with each other. A new study shows how domestic cats send signals to each other using odors derived from families of bacteria living in their anal glands. 

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Ancient cycad lineages that survived the extinction of the dinosaurs may have done so by relying on symbiotic bacteria in their roots to fix atmospheric nitrogen. The finding came from an effort to understand ancient atmospheres, but became an insight into plant evolution instead.

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Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.

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A new metal-organic coating protects bacterial cells from damage without impeding their growth or function. The coated bacteria, which produce ammonia, could make it much easier for farmers to deploy microbes as fertilizers.

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Researchers have unveiled a groundbreaking approach to label-free visualization of intracellular cargo trafficking in living cells, achieving high-speed and limitless observation capabilities. By developing a cargo-localization interferometric scattering (CL-iSCAT) microscope, scientists meticulously tracked the intricate movements of numerous cargos in the bustling cellular world. Surprisingly, cells employ human-like strategies to manage their transport challenges.

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ALMA (Atacama Large Millimeter/submillimeter Array) has demonstrated the highest resolution yet with observations of an old star. The observations show that the star is surrounded by a ring-like structure of gas and that gas from the star is escaping to the surrounding space. Future observations with the newly demonstrated high resolution are expected to elucidate, not only the end of a star's life, but also the beginning, when planets are still forming.

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Planetary rovers, which help humanity explore other planets, can deviate from their targeted paths or get stuck due to slipping on loose soil. To combat this problem, researchers have developed a novel system for rovers to detect their slip condition from the change in the shape of their chassis. This novel technology, inspired by human muscles, can lead to advanced sensing technologies that make travel safer for unmanned vehicles.

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Recently, morning omelets and holiday dinners have gotten more expensive. One likely cause is bird flu, outbreaks of which led to the deaths of millions of chickens and turkeys from infection or culling in 2022, according to the U.S. Department of Agriculture, and which still demands rigorous monitoring of wild populations. Now, researchers have developed a method that detected infectious bird flu virus in wetlands frequented by waterfowl.

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Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.

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Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles. 

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Astronomers have used recent observations made with the James Webb Space Telescope to study the atmosphere of the nearby exoplanet WASP-107b. Peering deep into the fluffy atmosphere of WASP-107b they discovered not only water vapor and sulfur dioxide, but even silicate sand clouds. These particles reside within a dynamic atmosphere that exhibits vigorous transport of material.

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Researchers have found that the deadly deformed wing virus (DMV) in bees may have evolved to be less deadly in at least one U.S. forest. The findings could have implications for preventing or treating the virus in managed colonies, researchers said.

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Data from a NASA mission to map dark matter around galaxy clusters has been saved by a new recovery system. The system allowed the retrieval of gigabytes of information, even after communication failed and the balloon-based telescope was damaged in the landing process.

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A student has measured the optical depth of Saturn's rings using a new method based on how much sunlight reached the Cassini spacecraft while it was in the shadow of the rings.

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Chemists have developed a new tool for detecting interactions between sugars and lectins, a discovery that could help in the fight against diseases like cancer.