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Categories: Biology: Microbiology, Ecology: Extinction

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A promising antibody failed testing. This is good news for developing a broad-spectrum antidote against the world's most dangerous snake venoms.

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Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced supersulfide are unclear. Now, using a strategically engineered yeast mutant with a deficient CARS gene, researchers from Japan have shown that supersulfides control cell longevity by mediating mitochondrial energy metabolism and regulating protein quality.

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Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes the toxicity that is a common feature of similar Fischer-carbene synthetic methodologies, and was used to synthesize the scaffold of the thienamycin antibiotic in high yield. This work is an important advancement in sustainable chemistry that should benefit drug development and other chemical syntheses.

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Identification of genes under recent selection provides insights into the molecular mechanisms of human-related adaptation in Candida pathogens. The study reveals both known and novel genetic variants associated with drug resistance, offering potential targets for improved antifungal therapies.

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To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.

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The number of infections by the tick-borne TBE virus that are not detected by health services is far higher than previously assumed. This has been shown in a new study of Swedish blood donors.

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In a new study, researchers have discovered how a system of proteins, called TamAB, helps Salmonella survive under the harsh conditions inside macrophages.

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An international team of scientists has uncovered the ocean's intricate web of microbial interactions across depths. Their research provides crucial insights into the functioning of ocean ecosystems.

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Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.

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The so-called Rice Yellow Mottle Virus (for short: RYMV) is responsible for high crop losses in Africa, particularly among small-scale farmers. A research team has now produced rice lines that are resistant to the disease by means of genome editing. The rice varieties are a preliminary step toward being able to generate resistant locally adapted elite varieties for small-scale food producers in Africa.

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Researchers have analyzed the rise of antibiotic resistance over the last 20 years in the UK and Norway, highlighting that antibiotic use is not the only factor in the increase.

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The sun has just set on a quiet mudflat in Australia's Northern Territory; it'll set again in another 19 hours. A young moon looms large over the desolate landscape. No animals scurry in the waning light. No leaves rustle in the breeze. No lichens encrust the exposed rock. The only hint of life is some scum in a few puddles and ponds. And among it lives a diverse microbial community of our ancient ancestors.

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Research using thermal imaging of numbats in Western Australia has found that during hot weather the endangered animals are limited to as little as ten minutes of activity in the sun before they overheat to a body temperature of greater than 40 C.

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Sharks have persisted as powerful ocean predators for more than 400 million years. They survived five mass extinctions, diversifying into an amazing variety of forms and lifestyles. But this ancient lineage is now among the world's most threatened species groups due to overexploitation in poorly regulated fisheries and the proliferation of wasteful finning practices.

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With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.

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The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

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Recent findings have identified a potential new link to signs of skin aging -- the skin microbiome, the collection of microorganisms that inhabits our skin.

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Scientists have long known that some viruses and bacteria begin infections by latching first onto sugar molecules on the surfaces of cells lining the sinuses and throat of mammals, including humans. Viral particles, for instance, can attach to these molecules, called sialic acids, or SAs, like keys fitting into locks.

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Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.

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Picrodontids -- an extinct family of placental mammals that lived several million years after the extinction of the dinosaurs -- are not primates as previously believed.