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Categories: Biology: Microbiology, Ecology: Extinction

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Researchers have refined an innovative method for measuring the activity level of microbes and linking that to their individual genetic code, providing new insights into the microbial communities that thrive in extreme environments.

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Scientists have discovered a new class of antibiotics with potent activity against multi-drug resistant bacteria, and have shown that it cures bloodstream infections in mice. Two publicly-funded initiatives dedicated to advancing early-stage antibiotic development, ENABLE and ENABLE-2, provided the resources and expert support without which this antibiotic would not have been developed.

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Using cutting-edge computational methods and supercomputing infrastructure, researchers have built the largest and most detailed bird family tree to date -- an intricate chart delineating 93 million years of evolutionary relationships between 363 bird species, representing 92% of all bird families. The updated tree reveals sharp increases in effective population size, substitution rates and relative brain size in early birds in the aftermath of the mass extinction event that wiped out the dinosaurs 66 million years ago. And by closely examining one of the branches of this tree, researchers found that flamingos and doves are more distantly related than previous genome-wide analyses had shown.

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A broader past could mean a brighter future for Canada lynx in the U.S., according to recent research. The study indicates that lynx might do well in the future in parts of Utah, central Idaho and the Yellowstone National Park region, even considering climate change and the lack of lynx in those areas now. Using a model validated by historic records, researchers first found that in 1900, Canada lynx had more suitable habitat in the U.S. than the few northern corners of the country where they are found currently. The study showed the elusive big cat likely roamed over a larger area in the Pacific Northwest, Rocky Mountains, Great Lakes region and parts of New England.

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A research consortium provides evidence that social behavior and social status are reflected at the molecular level of gene activation (epigenome) in juvenile and adult free-ranging spotted hyenas. They analyzed non-invasively collected gut epithelium samples from both high-ranking and low-ranking female hyenas and showed that rank differences were associated with epigenetic signatures of social inequality, i.e., the pattern of activation or switching off of genes that regulate important physiological processes such as energy conversion and immune response in several genome regions.

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Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.

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Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.

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Vaccination not only reduces the severity of TB in infected cattle, but reduces its spread in dairy herds by 89%, research finds.

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Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.

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Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.

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Researchers have developed a new method to isolate HIV from samples more easily, potentially making it easier to detect infection with the virus. They focus on peptide nanofibrils (PNFs) on magnetic microparticles, a promising tool and hybrid material for targeted binding and separation of viral particles.

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How coral populations expand into new areas and sustain themselves over time is limited by the scope of modern observations. Going back thousands of years, a study provides geological insights into coral range expansions by reconstructing the composition of a Late Holocene-aged subfossil coral death assemblage in an unusual location in Southeast Florida and comparing it to modern reefs throughout the region. Findings offer a unique glimpse into what was once a vibrant coral reef assemblage and discover if history can repeat itself in the face of climate change.

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Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of anti-microbial medications to kill tuberculosis bacteria residing in the lungs.

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Climate change may dramatically affect the animal species observed in North American cities, according to a new study.

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Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.

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Researchers warn that today's hunting quotas of about 3,000 animals pose a risk to the long-term survival of the grey seal in the Baltic Sea. The conclusions of this new study are based on statistics from 20th century seal hunting and predictions of future climate change.

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Anthropologists created a computational model to predict the likelihood of animal extinctions based on the complex interaction of hunting and environmental change.

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An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.

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Evolutionary biologists have unearthed a new species of tiger beetle, deemed Eunota houstoniana, honoring the Houston region where it predominantly resides.

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Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.