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Categories: Biology: Microbiology, Mathematics: Statistics

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Researchers describe a new manner of detecting microbial infection that intercepts pathogen-derived signals of growth to assess the relative threat of virulent bacteria. A nuclear hormone receptor in the nematode C. elegans senses a toxic metabolite produced by the bacterial pathogen Pseudomonas aeruginosa to activate innate immunity. These data reveal an ancient strategy that informs the origins of pathogen detection and may be among the most primordial forms of immune sensing in animals.

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The DNA sequence of a gene in wheat responsible for resisting a devastating virus has been discovered, providing vital clues for managing more resistant crops and maintaining a healthy food supply.

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New methodology and tools provide an opportunity to watch in unprecedented detail as a phage attacks a bacterium.

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Mineral particles played a key role in raising oxygen levels in the Earth's atmosphere billions of years ago, with major implications for the way intelligent life later evolved, according to new research.

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Researchers have mapped the sparse life hidden away in salt domes, rocks and crystals at Salar de Pajonales at the boundary of the Chilean Atacama Desert and Altiplano. Then they trained a machine learning model to recognize the patterns and rules associated with their distributions so it could learn to predict and find those same distributions in data on which it was not trained. In this case, by combining statistical ecology with AI/ML, the scientists could locate and detect biosignatures up to 87.5 percent of the time and decrease the area needed for search by up to 97 percent.

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Once upon a time, prevailing scientific opinion might have pronounced recently published research as unneeded. Now, climate change implications have heightened the need for this line of research. Flowers emit scent chemicals called volatile organic compounds (VOCs). Earlier this year, a study identified a protein that plays a key role in helping petunias emit volatiles.

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The findings offer a new way to understand how some ants become total layabouts.

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Neglected by government officials and medical professionals, parasitic infections can lead to lifelong health consequences, according to a biological anthropologist.

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Livestock farming produces large quantities of greenhouse gases, especially methane, which is particularly harmful to the climate. Among other things, it escapes during the storage of animal excrement, the slurry. A study now shows that methane emissions can be reduced by 99 percent through simple and inexpensive means. The method could make an important contribution to the fight against climate change.

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An international team of bee researchers has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors. This also provides insights into how social behavior is located in the brain.

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Bald eagles are often touted as a massive conservation success story due to their rebound from near extinction in the 1960s. But now a highly infectious virus may put that hard-fought comeback in jeopardy. New research showed highly pathogenic avian influenza, also known as H5N1, is killing off unprecedented numbers of mating pairs of bald eagles.

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Researchers have discovered a strong immunological effect of the molecule LecB -- and a way to prevent it.

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New research in mice shows bacteria hijack communication between nerve and immune cells in the meninges -- the protective layers that shield the brain from infection. The experiments detail step by step how bacteria activate pain receptors and initiate a signaling cascade that disables immune cells and culminates in bacterial invasion of the brain. The findings provide much-needed understanding into a critical window during the early stages of bacterial invasion when intervention could halt the spread of infection. The results point to therapeutic pathways for new treatments of bacterial meningitis, an often-fatal disease that can leave survivors with serious neurologic damage.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Researchers have identified gut bacteria that are associated with dementia with Lewy bodies. Changing the levels of three bacteria, Collinsella, Ruminococcus, and Bifidobacterium, may delay the onset and progression of this neurodegenerative disease.

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A research team has shown that, as early as the first days of infection, HIV is able to create reservoirs where it will hide and persist during antiretroviral therapy.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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Scientists who study the origins and evolution of the plague have examined hundreds of ancient human teeth from Denmark, seeking to address longstanding questions about its arrival, persistence and spread within Scandinavia.