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Categories: Biology: Microbiology, Physics: Optics
Published Malaria vaccine candidate appears safe and produces promising immune response in a cohort of Tanzanian infants
(via sciencedaily.com) Original source An experimental malaria vaccine appears safe and promotes an immune response in African infants, one of the groups most vulnerable to severe malaria disease. There is currently only one malaria vaccine, 'RTS,S' that is approved by the World Health Organization and offers partial disease protection. However, in the results of the early-stage phase Ib trial, researchers find that targeting RH5 -- a protein that the malaria pathogen Plasmodium falciparum uses to invade red blood cells -- can generate a promising immune response that is most pronounced in an infant cohort.
Published Mechanism underlying bacterial resistance to the antibiotic albicidin revealed
(via sciencedaily.com) Original source A new analysis shows that infectious bacteria exposed to the antibiotic albicidin rapidly develop up to a 1,000-fold increase in resistance via a gene amplification mechanism.
Published Researchers engineer bacteria that can detect tumor DNA
(via sciencedaily.com) Original source Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.
Published Making molecules dance to our tune reveals what drives their first movements
(via sciencedaily.com) Bringing ultrafast physics to structural biology has revealed the dance of molecular 'coherence' in unprecedented clarity.
Published Gut microbiome can increase risk, severity of HIV, EBV disease
(via sciencedaily.com) Original source Researchers created a germ-free mouse model to evaluate the role of the microbiome in the infection, replication, and pathogenesis of HIV and the Epstein-Barr virus, the virus that can cause mononucleosis and other serious diseases.
Published Common cold virus linked to potentially fatal blood clotting disorder
(via sciencedaily.com) Original source A new observation suggests that a life-threatening blood clotting disorder can be caused by an infection with adenovirus, one of the most common respiratory viruses in pediatric and adult patients.
Published Researchers find new pathway for HIV invasion of cell nucleus
(via sciencedaily.com) Original source A study has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.
Published Gastrointestinal viruses all but disappeared during COVID -- but surged back two years on
(via sciencedaily.com) Original source Following the first stay-at-home orders issued in the U.S. to curb the spread of COVID-19, gastrointestinal viruses such as norovirus, rotavirus and adenovirus all but disappeared from California communities, and remained at very low levels for nearly 2 years, according to new research.
Published Synthetic antibiotic could be effective against drug-resistant superbugs
(via sciencedaily.com) Original source A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.
Published Sugars in breastmilk could help treat infections, prevent preterm births
(via sciencedaily.com) Original source Breastfeeding has long been used as a method to help keep newborns healthy and protected against a variety of diseases. But certain sugars naturally found in breastmilk could also help prevent infections before a baby arrives. Researchers have found that these sugars can stop a common prenatal infection in human tissues and pregnant mice. This could someday help people avoid preterm births or complications without the need for additional antibiotics.
Published Molnupiravir administered at human effect size-equivalent dose blocks SARS-CoV-2 transmission in ferrets, researchers find
(via sciencedaily.com) Original source Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), provide equivalent therapeutic benefit in preventing severe COVID-19 in animal models, but only molnupiravir efficiently blocked SARS-CoV-2 transmission when administered at a human effect size-equivalent dose, according to a new study.
Published Treatments for poxviruses -- including those causing mpox and smallpox -- may already exist in licensed drugs
(via sciencedaily.com) Original source The drug tecovirimat is currently in use for the treatment of mpox -- the disease caused by monkeypox virus -- that spread worldwide in 2022. Tecovirimat is an anti-poxviral drug, and its use is driving the emergence of drug-resistant variants of the monkeypox virus. Scientists have identified how monkeypox virus exploits a cellular protein to evade host defenses, allowing it to replicate and spread better. Existing drugs -- developed to treat other viral infections -- also target this cellular protein. When tested against a range of poxviruses, including monkeypox, these drugs were found to have antiviral effects in all cases.
Published Technology advance could expand the reach of 3D nanoprinting
(via sciencedaily.com) Researchers have developed an easy-to-build, low-cost 3D nanoprinting system that can create arbitrary 3D structures with extremely fine features. The new 3D nanoprinting technique is precise enough to print metamaterials as well as a variety of optical devices and components such as microlenses, micro-optical devices and metamaterials.
Published Researchers use SPAD detector to achieve 3D quantum ghost imaging
(via sciencedaily.com) Researchers have reported the first 3D measurements acquired with quantum ghost imaging. The new technique enables 3D imaging on a single photon level, yielding the lowest photon dose possible for any measurement.
Published Remission from HIV-1 infection: Discovery of broadly neutralizing antibodies that contribute to virus control
(via sciencedaily.com) Original source Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023.
Published Potential novel breakthrough treatment for fungal infections
(via sciencedaily.com) Original source Fungal infections are killing thousands of Americans each year, some with a morbidity rate of nearly 80%. To make matters worse, only a handful of antifungal treatments are available, and even those are becoming less effective as fungi become more resistant. However, researchers recently published findings indicating that a novel breakthrough treatment may have been discovered.
Published Uncovering the Auger-Meitner Effect's crucial role in electron energy loss
(via sciencedaily.com) Original source Defects often limit the performance of devices such as light-emitting diodes (LEDs). The mechanisms by which defects annihilate charge carriers are well understood in materials that emit light at red or green wavelengths, but an explanation has been lacking for such loss in shorter-wavelength (blue or ultraviolet) emitters.
Published Self-supervised AI learns physics to reconstruct microscopic images from holograms
(via sciencedaily.com) Researchers have unveiled an artificial intelligence-based model for computational imaging and microscopy without training with experimental objects or real data. The team introduced a self-supervised AI model nicknamed GedankenNet that learns from physics laws and thought experiments. Informed only by the laws of physics that universally govern the propagation of electromagnetic waves in space, the researchers taught their AI model to reconstruct microscopic images using only random artificial holograms -- synthesized solely from 'imagination' without relying on any real-world experiments, actual sample resemblances or real data.
Published How the Epstein-Barr virus transforms B cells
(via sciencedaily.com) Original source Epstein-Barr virus (EBV) infection is known to convert resting B lymphocytes into immortal cells that continuously multiply, leading to posttransplant lymphoproliferative disorder (PTLD). Researchers have now uncovered the molecular mechanisms of this growth transformation, demonstrating the crucial role of the cancer-related gene IMPDH2 and nucleolar enlargement. Additionally, the research revealed strong evidence supporting the efficacy of mycophenolate mofetil, an approved immunosuppressant, in inhibiting PTLD, highlighting its therapeutic significance.
Published Astonishing complexity of bacterial circadian clocks
(via sciencedaily.com) Original source Bacteria make up more than 10% of all living things but until recently we had little realization that, as in humans, soil bacteria have internal clocks that synchronize their activities with the 24-hour cycles of day and night on Earth. New research shows just how complex and sophisticated these bacterial circadian clocks are, clearing the way for an exciting new phase of study.