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Categories: Biology: Microbiology, Engineering: Graphene

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Leading edge technology has uncovered secrets about a world-renowned fossil hoard that could offer vital clues about early life on Earth. Researchers who analyzed the 400 million-year-old cache, found in rural north-east Scotland, say their findings reveal better preservation of the fossils at a molecular level than was previously anticipated.

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An international research team produced the first large-scale analysis of more than 400 newly sequenced and existing Omnitrophota genomes, uncovering new details about their biology and behavior.

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It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery -- until possibly now. Researchers have found that female mouse and human Natural Killer cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.

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A new process that lets scientists chemically cut apart and stitch together nanoscopic layers of two-dimensional materials -- like a tailor altering a suit -- could be just the tool for designing the technology of a sustainable energy future. Researchers have developed a method for structurally splitting, editing and reconstituting layered materials, called MAX phases and MXenes, with the potential of producing new materials with very unusual compositions and exceptional properties.

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Pneumococcal disease leads to over three million hospitalizations and hundreds of thousands of deaths annually. A new study suggests that the FDA-approved drug Fomepizole may reduce disease severity in the lungs of mice with some forms of bacterial pneumonia and enhance the efficacy of the antibiotic erythromycin as well.

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New research makes it likely that proteins responsible for activating mosquito sperm can be shut down, preventing them from swimming to or fertilizing eggs.

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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.

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The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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New research has established a link between western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease.

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Researchers have found that an outbreak of highly pathogenic avian influenza (HPAI) was associated with the deaths of more than 330 New England harbor and gray seals along the North Atlantic coast in June and July 2022, and the outbreak was connected to a wave of avian influenza in birds in the region.

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In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

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Despite recent advancements, many highly sensitive diagnostic tests for viral diseases still require complicated techniques to prepare a sample or interpret a result, making them impractical for point-of-care settings or areas with few resources. But now, a team has developed a sensitive method that analyzes viral nucleic acids in as little as 20 minutes and can be completed in one step with 'glow-in-the-dark' proteins.

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A new study has found evidence of cheesemaking, using milk from multiple animals in Late Neolithic Poland.

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Thanks to technological advances in microbial DNA analysis, researchers have discovered that mountaineers' boots aren't the only things leaving footprints on the world's tallest mountain. When someone sneezes on Everest, their germs can last for centuries.

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The relatively simple and low-cost procedure could empower laboratories in low-resource areas to generate nanobodies against SARS-CoV-2, as well as other viruses.

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A new study explores exactly what leads to the generation of Th17 cells -- an important subtype of cells in the intestine -- and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut.

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Extremely long tail provides structural window into how bacteria-infecting viruses called phages assemble.

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A study of chicken farms in the West found that high winds increased the prevalence of Campylobacter in outdoor flocks, a bacterial pathogen in poultry that is the largest single cause of foodborne illness in the U.S. Researchers found that about 26% of individual chickens had the pathogen at the 'open environment' farms in the study, which included organic and free-range chicken farms. High winds the week prior to sampling and the farms' location in more intensive agricultural settings were linked to a greater prevalence of Campylobacter.

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Researchers sheds light on a face-off in the intestines between the immune system and a bacterial pathogen whose family members cause gastrointestinal disease and the plague. The team's insights may extend to other chronic infections and could inform the development of immunotherapies capable of fully extinguishing such diseases.