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Categories: Biology: Microbiology, Chemistry: Inorganic Chemistry

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Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue. The findings offer a simpler, less time-consuming way for medical researchers to program muscle cell alignment, which is strongly tied to healthy muscle function.

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The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. Investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

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Researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive. Malaria parasites in infected patients being treated with atovaquone tend to develop a resistance to the drug. Because of this, atovaquone by itself is not used as a malaria treatment nor has not been seen as a strong candidate for use as a preventive. 

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Researchers conducted a phase I pilot study to assess the feasibility of using potato starch as a dietary intervention to modify the gut microbiome in bone marrow transplant patients. The study is the first part of a two-phase ongoing clinical trial evaluating the effect of modifying the microbiome on the incidence of graft-versus-host disease (GVHD), a major complication that develops in up to half the patients who receive a bone marrow transplant and can lead to injury and death.

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While sea freight is recognised as a pathway for the movement of exotic organisms, there is little research that has quantified the risk. Soil collected from the external surfaces of sea freight was found to support live microorganisms, worms, seeds and insects, including various regulated biosecurity organisms. The research confirms that shipping containers provide a pathway for the movement of exotic species.

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Researchers have found a gene associated with longevity in golden retrievers, one of the most popular breeds of dogs.

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A plant geneticist and computational biologist teamed up to decipher the unpredictability of natural and engineered mutations in tomatoes. They discovered some combinations of mutations behave as expected while others are more erratic. Their work may help scientists find some order in the chaos of evolution and genome editing.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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New findings point to 2 additional probiotics as potential treatments for high blood pressure.

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Engineers have developed a recipe to make a certain class of ceramics tougher and more resistant to cracking. The newfound toughness of these ceramics paves the way for their use in extreme applications, such as spacecraft and other hypersonic vehicles.

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A research team has discovered that parasites manipulate their hosts using stolen genes that they likely acquired through a phenomenon called horizontal gene transfer.

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Scientists  have developed a genome-scale metabolic model or 'subway map' of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully identified two compounds that selectively target routes only used by Lyme disease to infect a host.

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Many people have experienced a muddy off-flavor in farmed fish. While the aquaculture industry has known about the problem for 20 years, it continues to impact the consumption of otherwise healthy and potentially sustainable fish. Now, researchers have been able to pinpoint exactly when the off-flavors emerge. And this can make it easier to deal with the compounds that turn people away from farmed fish.

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The explosive rise in tick-borne diseases in many parts of the United States over the last five decades represents a major public health threat that demands innovative solutions, warns a group of scientists. They outline why the stakes are so high and describe some potential solutions. Possible solutions include a new class of vaccines for humans and even for the animals that carry the ticks.

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Researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.

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Particle accelerators are crucial tools in a wide variety of areas in industry, research and the medical sector. The space these machines require ranges from a few square meters to large research centers. Using lasers to accelerate electrons within a photonic nanostructure constitutes a microscopic alternative with the potential of generating significantly lower costs and making devices considerably less bulky. Until now, no substantial energy gains were demonstrated. In other words, it has not been shown that electrons really have increased in speed significantly. Two teams of laser physicists have just succeeded in demonstrating a nanophotonic electron accelerator.

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A vaccine designed to protect against three different deadly coronaviruses shows success in mouse studies, demonstrating the viability of a pan-coronavirus vaccine developed by researchers at the Duke Human Vaccine Institute.

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A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies.

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Children fall broadly into four eating categories, according to new research, and parents feed their children differently depending on those categories.  

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A new study focuses on using computer algorithms to generate adaptations to molecules in compounds for existing and potential medications that can improve those molecules' ability to bind to the main protease, a protein-based enzyme that breaks down complex proteins, in SARS-CoV-2, the virus that causes COVID-19.