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Categories: Biology: Microbiology, Chemistry: Inorganic Chemistry

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Scientists have amassed genome data for dozens of 'magic mushroom' isolates and cultivars, with the goal to learn more about how their domestication and cultivation has changed them. The findings may point the way to the production of intriguing new cultivars, say the researchers.

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While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.

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Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.

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New research has revealed a previously unknown process through which pathogens are able to defeat a cell's defense mechanisms with physical force. The discovery represents a potential game-changer in the fight against intracellular pathogens, which cause infectious diseases such as tuberculosis, malaria and chlamydia.

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A simple-to-apply, needle-free vaccine patch is being developed to protect people from the potentially deadly mosquito-borne Zika virus.

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Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.

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Hydrogen is a building block for the energy transition. To obtain it with the help of solar energy, researchers have developed new high-performance nanostructures. The material holds a world record for green hydrogen production with sunlight.

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Friction is hard to predict and control, especially since surfaces that come in contact are rarely perfectly flat. New experiments demonstrate that the amount of friction between two silicon surfaces, even at large scales, is determined by the forming and rupturing of microscopic chemical bonds between them. This makes it possible to control the amount of friction using surface chemistry techniques.

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For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.

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A collaborative research team has discovered a new process for making anhydrides that promises improvements in costs and sustainability.

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Long before researchers discovered the electron and its role in generating electrical current, they knew about electricity and were exploring its potential. One thing they learned early on was that metals were great conductors of both electricity and heat. And in 1853, two scientists showed that those two admirable properties of metals were somehow related: At any given temperature, the ratio of electronic conductivity to thermal conductivity was roughly the same in any metal they tested. This so-called Wiedemann-Franz law has held ever since -- except in quantum materials. Now, a theoretical argument put forth by physicists suggests that the law should, in fact, approximately hold for one type of quantum material, the cuprate superconductors.

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To ensure that vaccines provide strong and lasting immunization, it is often necessary to supplement the actual vaccine (antigen) with additives that stimulate the immune system: adjuvants. Today, only a few substances have been approved for use as adjuvants. A research team has now introduced a spectrum of potential adjuvants. They started with the immune stimulant ?-glactosyl ceramide (?-GalCer) and synthesized many different variants from a set of four building blocks.

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Farmland often harbors a multitude of pathogens which attack plants and reduce yields. A research team has now shown that inoculating the soil with mycorrhizal fungi can help maintain or even improve yields without the use of additional fertilizers or pesticides. In a large-scale field trial, plant yield increased by up to 40 percent.

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Found in fishing nets, carpet, clothing, Nylon-6 is a major contributor to plastic pollution, including ocean pollution. Now, chemists have developed a new catalyst that quickly, cleanly and completely breaks down Nylon-6 in a matter of minutes -- without generating harmful byproducts. Even better: The process does not require toxic solvents, expensive materials or extreme conditions, making it practical for everyday applications. In experiments, the new process recovered 99% of the polymer's building blocks, which can then be upcycled into higher-value products.

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A new study tackles the mystery of why bacteria often carry diverse ranges of weapons. The findings show that different weapons are best suited to different competition scenarios. Short-range weapons help bacteria to invade established communities; long-range weapons are useful once established.

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Researchers have discovered that growing bacteria on agar mixed with organs is an efficient and effective way to study infectious pathogens.

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A new bacterial species discovered at the deep-sea hydrothermal vent site 'Crab Spa' provides a deeper understanding of bacterial evolution.

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The Second Plague Pandemic of the mid-14th century, also known as the Black Death, killed 30-60 percent of the European population and profoundly changed the course of European history. New research suggests that this plague, potentially through resulting changes in diet and hygiene, may also be associated with a shift in the composition of the human oral microbiome toward one that contributes to chronic diseases in modern-day humans.  

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Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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Researchers have developed an AI model that can predict where a drug molecule can be chemically altered.