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Categories: Biology: Biotechnology, Biology: Evolutionary

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Scientists have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.

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Researchers have discovered how amino acids activate a key cell, TORC1, which is a master regulator in living organisms that controls whether cells grow or recycle their contents in yeast. Notably, the team found that the amino acid cysteine is sensed by a protein called Pib2 and that the two bind together to trigger TORC1. This is important because faulty TORC1 has been linked to disease such as cancer.

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A research group found that in female fruit flies, microorganisms enhance reproductive function, boosting the number of cells that form eggs and the number of mature eggs. This is done by controlling the release of hormones to speed up cell division in the ovaries, and limiting programmed cell death. These findings could improve reproductive medicine and could aid the development of new methods to enhance fertility.

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Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic resistance.

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Researchers have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

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A new technique to clone and reassemble DNA, dubbed CReATiNG, could simplify and lower the cost to make synthetic chromosomes. Potential applications are numerous, including pharmaceutical production, biofuel generation, cancer therapies, and environmental cleanup using modified organisms. The method adds a powerful, versatile tool to the burgeoning field of synthetic biology.

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Scientists have discovered that plants send tiny, innocuous-seeming lipid 'bubbles' filled with RNA across enemy lines, into the cells of the aggressive mold. Once inside, different types of RNA come out to suppress the infectious cells that sucked them in.

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Researchers describe unusual trilobite fossils prepared as thin sections showing the 3D soft tissues during enrollment. The study reveals the soft undersides of enrolled trilobites and the evolutionary mechanism that allows arthropods to enroll their bodies for protection from predators and adverse environmental conditions.

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Researchers have studied the relationships between five closely related species of larks that occur in Africa south of the Sahara. Two of these have not been observed for decades, so the researchers analyzed DNA from museum specimens, some of which were over 100 years old.

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A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.

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The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.

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Researchers have engineered bacteria that can produce two chemical products at the same time from underutilized plant fiber. And unlike humans, these multitasking microbes can do both things equally well. The discovery could help make biofuels more sustainable and commercially viable.

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Aquaporin (Aqp) 10 water channels in humans allow the free passage of water, glycerol, urea, and boric acid across cells. However, Aqp10.2b in pufferfishes allows only the passage of water and glycerol and not urea and boric acid. Researchers sought to understand the evolutionary timeline that resulted in the variable substrate selection mechanisms among Aqp10s. Their results indicate that Aqp10.2 in ray-finned fishes may have reduced or lost urea and boric acid permeabilities through evolution.

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Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell's clock genes, which do exactly as you suspect from the name: regulate your body's rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia's potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.

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A newly identified protein helps poison dart frogs accumulate and store a potent toxin in their skin which they use for self-defence against predators.

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Wild North American grapes are now less of a mystery after researchers decoded and catalogued the genetic diversity of nine species of this valuable wine crop.

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Plants often develop communities with microorganisms in their roots, which influences plant health and development. Although the recruitment of these microbes is dictated by several factors, it is unclear whether the genetic variation in the host plants plays a role.

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In a new study of aardvarks, researchers spent months in sub-Saharan Africa collecting poop from the animal and concluded that aridification of the landscape is isolating them, which they say could have implications for their long-term survival.

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Scientists recently published findings indicating that Ebola virus creates and uses intercellular tunnels to move from cell to cell and evade treatments.

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Researchers have published an atlas of zebrafish development, detailing the gene expression programs that are activated within nearly every cell type during the first five days of development, a period in which embryos mature from a single cell into distinct cell types.