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Categories: Biology: Biotechnology, Biology: Evolutionary

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Researchers describe how gut-on-a-chip devices can bridge lab models and human biology. Modeling the microbiome is particularly difficult because of its unique environmental conditions, but through creative design, gut-on-a-chip devices can simulate many of these properties, such as the gut's anaerobic atmosphere, fluid flow, and pulses of contraction/relaxation. Growing intestinal cells in this environment means that they more closely resemble human biology compared to standard laboratory cell cultures.

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What is the origin of the ancestors of present-day fish? What species evolved from them? A 50-year-old scientific controversy revolved around the question of which group, the 'bony-tongues' or the 'eels', was the oldest. A study has just put an end to the debate by showing through genomic analysis that these fishes are in fact one and the same group, given the rather peculiar name of 'Eloposteoglossocephala'. These results shed new light on the evolutionary history of fish.

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Biochemists have succeeded in resurrecting the ancestral genes of five detoxifying enzymes which are present in all tetrapods to show how their divergence in function has occurred.

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After more than 30 years, botanists have rediscovered Thismia kobensis, a type of mysterious-looking rare plant commonly referred to as 'fairy lanterns'. Thismia kobensis was presumed extinct and the surprise rediscovery of this Japanese variety has illuminated hidden aspects of fairy lanterns that have puzzled and fascinated botanists for centuries.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Modern birds capable of flight all have a specialized wing structure called the propatagium without which they could not fly. The evolutionary origin of this structure has remained a mystery, but new research suggests it evolved in nonavian dinosaurs. The finding comes from statistical analyses of arm joints preserved in fossils and helps fill some gaps in knowledge about the origin of bird flight.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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Scientists who study the origins and evolution of the plague have examined hundreds of ancient human teeth from Denmark, seeking to address longstanding questions about its arrival, persistence and spread within Scandinavia.

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Plants can move in ways that might surprise you. Some of them even show 'sleep movements,' folding or raising their leaves each night before opening them again the next day. Now, researchers offer convincing evidence for these nightly movements, also known as foliar nyctinasty, in fossil plants that lived more than 250 million years ago.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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The endangered Saimaa ringed seal is an Ice Age relict living in the highly labyrinthine Lake Saimaa, Finland. The newly published work shows that although individual seals have greatly reduced genetic variation, the loss of variation has been complementary, preserving the adaptive potential of the whole population.

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When scientists disabled a single regulatory gene in a species of sea anemone, a stinging cell that shoots a venomous miniature harpoon for hunting and self-defense shifted to shoot a sticky thread that entangles prey instead, according to a new study.

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A new model offers a possible solution to the scientific question of why neutral sequences, sometimes referred to as 'junk DNA', are not eliminated from the genome of living creatures in nature and continue to exist within it even millions of years later.

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Geckos can use their tongue to differentiate their own odor from that of other members of their species, as researchers have shown in a new experimental study. The findings show that geckos are able to communicate socially, meaning that they are more intelligent than was previously assumed.

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Fish, the most biodiverse vertebrates in the animal kingdom, present evolutionary biologists a conundrum: The greatest species richness is found in the world's tropical waters, yet the fish groups that generate new species most rapidly inhabit colder climates at higher latitudes. A new study helps to explain this paradox. The researchers discovered that the ability of fish in temperate and polar ecosystems to transition back and forth from shallow to deep water triggers species diversification. Their findings suggest that as climate change warms the oceans at higher latitudes, it will impede the evolution of fish species.

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Bee researchers have identified a new gene in honeybees, which is responsible for the dimorphic eye differentiation between males and females of the species. The researchers have now presented this gene and the evolutionary genetic conclusions they have drawn from it.

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Monkeyflowers glow in a rich assortment of colors, from yellow to pink to deep red-orange. But about 5 million years ago, some of them lost their yellow. Botanists now explain what happened genetically to jettison the yellow pigment, and the implications for the evolution of species.

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In certain Lake Tanganyika cichlids breeding in empty snail shells, there are two extreme sizes of males: giants and dwarfs. Researchers have analyzed the genomes of these fish and found out how the peculiar sizes of males and females evolved in conjunction with the genetic sex determination mechanism.