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Categories: Biology: Genetics, Geoscience: Earth Science

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Tweaks to the mitochondrial genome hold the potential for better hybrid seed production or to introduce seedless fruits.

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Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

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Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.

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Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.

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Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.

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A new study updates the planetary boundary framework and shows human activities are increasingly impacting the planet and, thereby, increasing the risk of triggering dramatic changes in overall Earth conditions.

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During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.

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If the Chicago region replaced 30% of all on-road combustion-engine vehicles -- including motorcycles, passenger cars and trucks, buses, refuse trucks and short- and long-haul trucks -- with electric versions, it would annually save more than 1,000 lives and over $10 billion, according to a new study.

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Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.

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Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.

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A pioneering study has shed new light on North African humid periods that have occurred over the past 800,000 years and explains why the Sahara Desert was periodically green.

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A new study confirms that planting hedges between roadsides and school playgrounds can dramatically reduce children's exposure to traffic-related particle pollution.

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HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.

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Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.

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Researchers have uncovered new genetic insights into Staphylococcus aureus, revealing what makes the bacterium so dangerous when it enters the blood.

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New research shows that amplified global warming in the Canadian High Arctic drove a profound shift in the structure of a river network carved into a permafrost landscape in only 60 years.

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A review of almost 1000 studies on the effects of climate change and extreme weather events on rivers around the world has found an overall negative effect on water quality in rivers globally. An international team of experts sourced from every continent, conducted between 2000-2022.

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Peppers are a versatile, flavorful, and widely popular crop, used not only as a healthy food source but also for their medicinal properties. Scientists have now sequenced the genomes of key cultivated and wild pepper species, offering unprecedented insights into pepper evolution, domestication, and genetic diversity.

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Climate experts project a decline in the frequency of future tropical storms but an increase in their strength across the Ganges and Mekong basins allowing for better future planning.

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An international team of scientists has successfully conducted large-scale helicopter-based observations along the coast of East Antarctica and has identified pathways through which warm ocean water flows from the open ocean into ice shelf cavities for the first time.