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Categories: Biology: Cell Biology, Paleontology: Climate

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A new study explores exactly what leads to the generation of Th17 cells -- an important subtype of cells in the intestine -- and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut.

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With the aid of some sea slugs, chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons. The team has shown that the orientation of a single amino acid -- in this case, one of dozens found in the neuropeptide of a sea slug -- can dictate the likelihood that the peptide activates one neuron receptor versus another. Because different types of receptors are responsible for different neuronal activities, the finding points to another means by which a brain or nervous system can regulate the labyrinthine, life-sustaining communication among its cells.

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Extremely long tail provides structural window into how bacteria-infecting viruses called phages assemble.

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The agriculture industry is under pressure to adopt sustainable and precise agricultural practices that enable more efficient use of resources due to worsening environmental conditions resulting from climate change, an ever-expanding human population, limited resources, and a shortage of arable land. As a result, developing delivery systems that efficiently distribute micronutrients, pesticides, and antibiotics in crops is crucial to ensuring high productivity and high-quality produce while minimising resource waste. However, current and standard practices for agrochemical application in plants are inefficient. These practices cause significant detrimental environmental side effects, such as water and soil contamination, biodiversity loss and degraded ecosystems; and public health concerns, such as respiratory problems, chemical exposure and food contamination.

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Researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced. The new mouse model shows milder cognitive traits compared to a previously studied Down syndrome mouse model.

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Scientists have done research that opens up a whole new world within our cells. Their study uncovers a vast network of interactions that assist cells in adjusting in real time to withstand stresses on our health.

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Meiotic recombination assures genetic variation during breeding. During meiotic prophase I, chromosomes are organized in a loop-base array by a proteinaceous structure called meiotic chromosome axis which is critical for meiotic recombination and genetically diverse gametes. An international research team reports the application of a TurboID (TbID)-based approach to identify proteins in proximity of meiotic chromosome axes in Arabidopsis thaliana. Not only known but also new meiotic proteins were uncovered.

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Scientists have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherpy CAR-T cells in patients with B cell lymphomas. Individualized microbiome information retreaved from patients' gut microbiomes prior to initiation of CAR T therapy could accurately predict their subsequent responsiveness to therapy, but only in the condition that these patients were not pre-treated with broad spectrum antibiotics.

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A whole new world of antibiotics is waiting inside the viruses that infect bacteria. Scientists are making it easier to study them.

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Geologists studying the Bakken Shale Formation discovered a critical kill mechanism behind a series of extinctions some 350 million years ago.

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Short-distance migration, which accounts for the vast majority of migratory movements in the world, is crucial for climate change adaptation, according to new research. Contrary to common assumptions, most migratory movements are people moving short distances, largely due to economic, social and environmental factors, such as climate change.

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Milutin Milankovitch hypothesized that the timing of glacial transitions has been controlled by the orbital parameters of the Earth, which suggests that there may be some predictability in the climate, a notoriously complex system. Now researchers propose a new paradigm to simplify the verification of the Milankovitch hypothesis. The new 'deterministic excitation paradigm' combines the physics concepts of relaxation oscillation and excitability to link Earth's orbital parameters and the glacial cycles in a more generic way.

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Previous models of Earth's recent (100 million years) geomorphology have been patchy at best. For the first time a detailed continuous model of the Earth's landscape evolution is presented, with potential for understanding long-term climate and biological development.

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A newly published study of a stalagmite found in Cave of the Mounds reveals previously undetected history of the local climate going back thousands of years. Researchers describe evidence for an ice age punctuated by massive and abrupt warming events across much of the Northern Hemisphere.

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Large-scale genomic analysis documents the migrations of Ice Age hunter-gatherers over a period of 30,000 years -- they took shelter in Western Europe but died out on the Italian peninsula.

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A new study reports on genomic data from a 23,000-year-old individual who lived in what was probably the warmest place of Europe at the peak of the last Ice Age. The oldest human genome recovered from the southern tip of Spain adds an important piece of the puzzle to the genetic history of Europe.

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Submarine landslides have a large tsunami potential and occurred on the central Norwegian shelf more frequently in the past than previously thought. Scientists investigate the Nyegga landslide off the coast of Norway. The submarine landslide occurred in the same area as the well-known Storegga event 8,150 years ago. The new findings suggest that approximately one-third of the seafloor material missing -- previously attributed to the Storegga event -- was removed by the Nyegga event 20,000 years ago. This raises questions about the frequency of large submarine landslides and their associated tsunami hazard.

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What we think of as the classic West Coast climate began just about 4,000 years ago, finds a study on climate trends of the Holocene era.

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A team of researchers is working to understand the details of the climate for the eastern portion of the United States from the Miocene, which unfortunately is a blank spot on paleo-climate maps. New findings suggest the future climate will be very close to the warmer, wetter, and more homogeneous climate similar to conditions experienced 5 million years ago.

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Geologists doing fieldwork in southeastern Utah's Cedar Mountain Formation found carbon isotope evidence that the site, though on land, experienced the same early Cretaceous carbon-cycle change recorded in marine sedimentary rocks in Europe. This ancient carbon-cycle phenomenon, known as the 'Weissert Event' was driven by large, sustained volcanic eruptions in the Southern Hemisphere that greatly increased carbon dioxide levels in the atmosphere and produced significant greenhouse climate effects over a prolonged time.