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Categories: Biology: Biochemistry, Biology: Cell Biology

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Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.

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New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.

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Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.

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Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.

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Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.

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Half of plant proteins in the EU come from rapeseed plants. Until now, the plant has only been used for oil and animal feed, as it is both bitter and unsafe for human consumption. In a new study, researchers have gotten closer to removing the plant's bitter substances, and in doing so, are paving the way for a new protein source to support the green transition.

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Newly developed 'smart' coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria, researchers report. The coatings integrate flexible sensors with a nanostructured antibacterial surface inspired by the wings of dragonflies and cicadas.

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Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.

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Because contrasting societal views have created an approach that simultaneously manages horses on the range as wildlife, livestock and pets, current U.S. government programs are incapable of succeeding, according to researchers.

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Researchers have proposed a new model for the evolution of higher brain functions and behaviors in the Hymenoptera order of insects. The team compared the Kenyon cells, a type of neuronal cell, in the mushroom bodies (a part of the insect brain involved in learning, memory and sensory integration) of 'primitive' sawflies and sophisticated honey bees. They found that three diverse, specialized Kenyon cell subtypes in honey bee brains appear to have evolved from a single, multifunctional Kenyon cell-subtype ancestor. In the future, this research could help us better understand the evolution of some of our own higher brain functions and behaviors.

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Researchers show that the migratory locust Locusta migratoria produces the compound phenylacetonitrile (PAN) to defend itself against feeding attacks by conspecifics as population density increases. Cannibalism rates increased in locusts that could no longer produce PAN. The researchers also identified the odor receptor for PAN in the locusts. They showed in animals with a PAN receptor that was no longer functional that it is necessary for the perception of PAN and the suppression of cannibalistic behavior. The discovery of an anti-cannibalism pheromone offers new approaches for locust control.

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Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science.

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Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.

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Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.

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For decades, scientists have used the amount of seaweed at the ocean's surface as a proxy for the health of coral reefs below. However, a new global study of more than 1,200 marine locations over a 16-year period reveals that this approach has been misleading -- and may even have hidden signs of reef stress.

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When the seeds of plants such as pea and sunflower are biofortified with zinc, the seedlings they quickly produce -- harvested as microgreens -- could both help to mitigate global malnutrition and boost the odds of people surviving a catastrophe.

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Researchers have exposed roundworms (a well-established model organism in biological research) to selective serotonin reuptake inhibitors (SSRIs), a class of drugs used for treating depression and anxiety. Surprisingly, this treatment improved the quality of aging females' egg cells.

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Most chromosomes have been around for millions of years. Now, researchers have revealed the dynamics of a new, very young chromosome in fruit flies that is similar to chromosomes that arise in humans and is associated with treatment-resistant cancer and infertility. The findings may one day lead to developing more targeted therapies for treating these conditions.

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Worldwide, growers lose between 10 and 23 per cent of their crops to fungal infection each year, despite widespread use of antifungals. An additional 10-20 per cent is lost post harvest. In a commentary in Nature, academics predict those figures will worsen as global warming means fungal infections are steadily moving polewards, meaning more countries are likely to see a higher prevalence of fungal infections damaging harvests.

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An international research team has for the first time successfully isolated ancient human DNA from a Paleolithic artefact: a pierced deer tooth discovered in Denisova Cave in southern Siberia. To preserve the integrity of the artefact, they developed a new, nondestructive method for isolating DNA from ancient bones and teeth. From the DNA retrieved they were able to reconstruct a precise genetic profile of the woman who used or wore the pendant, as well as of the deer from which the tooth was taken. Genetic dates obtained for the DNA from both the woman and the deer show that the pendant was made between 19,000 and 25,000 years ago. The tooth remains fully intact after analysis, providing testimony to a new era in ancient DNA research, in which it may become possible to directly identify the users of ornaments and tools produced in the deep past.