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Categories: Biology: Cell Biology, Engineering: Nanotechnology

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The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.

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Individual fish in schools scatter in unison when a predator is in their midst. Such precisely coordinated group movements and immobility during threats have long been observed in insects and mammals. Now, a brain pathway has been discovered that enables individual animals to rapidly coordinate a unified response, with no rehearsal required.

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Researchers have mapped out what a commonly-used form of phage looks like, which will help design better uses in future.

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Researchers have shown that extremophilic bacteria from high temperature marine environments can be used to reduce asbestos' toxicity.

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Engineers have developed a readily scalable method to optimize a silicon anode priming method that increases lithium-ion battery performance by 22% to 44%.

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Scientists have precisely identified base pairs of the human genome that remained consistent over millions of years of mammalian evolution, and which play a crucial role in human disease. The team analyzed the genomes of 240 mammals, including humans and identified base pairs that were 'constrained' -- meaning they remained generally consistent -- across mammal species over the course of evolution. The most constrained base pairs in mammals were over seven times more likely to be causal for human disease and complex trait, and over 11 times more likely when researchers looked at the most constrained base pairs in primates alone.

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Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.

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Engineers have developed a new sponge that can remove metals -- including toxic heavy metals like lead and critical metals like cobalt -- from contaminated water, leaving safe, drinkable water behind. In proof-of-concept experiments, the researchers tested their new sponge on a highly contaminated sample of tap water, containing more than 1 part per million of lead. With one use, the sponge filtered lead to below detectable levels.

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A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.

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Over 3,000 generations of laboratory evolution, researchers watched as their model organism, 'snowflake yeast,' began to adapt as multicellular individuals. In new research, the team shows how snowflake yeast evolved to be physically stronger and more than 20,000 times larger than their ancestor. Their study is the first major report on the ongoing Multicellularity Long-Term Evolution Experiment (MuLTEE), which the team hopes to run for decades.

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Comparing individual cells across corn, sorghum, and millet reveals evolutionary differences among these important cereal crops, according to a new study. The findings bring researchers closer to pinpointing which genes control important agricultural traits such as drought tolerance, which will help scientists faced with a changing climate adapt crops to drier environments.

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Rhinoceros belong to a mammalian order called odd-toed ungulates that also include horses and tapirs. They are found in Africa and Asia. Until recently, evidence suggested that throughout their evolutionary history, gamma-retroviruses such as Murine leukemia virus had not colonized their genomes, unlike most other mammalian orders. The colonization process is called retroviral endogenization and has resulted in most mammalian genomes being comprised of up to ten percent retroviral like sequences.

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One of the basic and crucial embryonic processes to unfold in virtually every living organism is the formation of hollow, tubular structures that go on to form blood vessels or a digestive tract, and through branching and differentiation, complex organs including the heart and kidneys. This study illuminates fundamental design principles of tubulogenesis for all chordates, including mammals.

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Small bats are bad at converting energy into muscle power. Surprisingly, a new study led by Lund University in Sweden reveals that this ability increases the faster they fly.

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A new drug candidate targeting E. coli in the gut is in phase 1 clinical trials. According to a new paper it may improve the well-being of blood cancer patients and reduce their mortality rate from E. coli infections.

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Researchers describe developing a super-resolution imaging platform technology to improve understanding of how nanoparticles interact within cells.

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Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

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Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.

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New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.

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Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.