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Categories: Biology: Cell Biology, Energy: Technology

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Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity. Scientists have discovered an exception to this rule. Namely, a group of divergent bacterial pathogens, including pneumococci, all share a small highly conserved protein sequence, which is both presented and recognized by human T cells in a conserved population-wide manner.

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Researchers have identified a previously unknown group of bacteria, called UBA868, as key players in the energy cycle of the deep ocean. They are significantly involved in the biogeochemical cycle in the marine layer between 200 and 1000 meters.

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Viruses like influenza A and Ebola invade human cells in a number of steps. Research teams investigated the final stages of viral penetration using electron tomography and computer simulations. So-called fusion pores, through which the viral genome is released into the host cell, play a central role in these processes. If they can be prevented from forming, the virus is also blocked. The Heidelberg scientists describe previously unknown mechanisms, which might lead to new approaches to prevent infections.

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The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.

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Craft brewers are continuously upping the ante and coming up with innovative ways to make or flavor their newest beers. Now, researchers are adding a new twist of their own, speeding up the brewing process with beer-making mini-robots or 'BeerBots.' The team shows that these self-propelled, magnetic packages of yeast can make the fermentation phase go faster and cut out the need to filter the beverage.

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Medication delivered by a novel gel cured 100% of mice with an aggressive brain cancer, a striking result that offers new hope for patients diagnosed with glioblastoma, one of the deadliest and most common brain tumors in humans.

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Researchers have developed a novel and highly efficient method for rapid antibiotic susceptibility testing using optical microscopy. The technique, called Optical Nanomotion Detection, is extremely rapid, single-cell sensitive, label-free, and requires only a basic traditional optical microscope, equipped with a camera or a mobile phone.

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A research team has shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus -- a bacterial species widely resistant to antibiotics.

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By studying green algae in Swedish lakes, a research team has succeeded in identifying which environmental conditions promote multicellularity. The results give us new clues to the amazing paths of evolution.

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Researchers developed a proof of concept for a superconducting highway that could transport vehicles and electricity, cooling the necessary superconductors with a pipeline of liquid hydrogen. Most magnetic levitation designs feature the superconductor inside the vehicle, which is suspended above a magnetic track. The authors decided to flip that arrangement upside down, putting the superconductor on the ground and giving each vehicle a magnet. The result is a system with multiple uses, placing it within the realm of affordability.

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Thanks to a novel combination of cryogenic transmission electron tomography and deep learning, EPFL researchers have provided a first look at the nanostructure of platinum catalyst layers, revealing how they could be optimized for fuel cell efficiency.

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An international team of researchers lays the foundation to examine how extracellular RNA and its carrier proteins found in bodily fluids function in a healthy as well as a diseased setting, potentially providing a means to accurately implement early detection and monitor disease processes.

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Engineers developed a method to create synthetic spider silk at high yields while retaining strength and toughness using mussel foot proteins.

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An AI strategy proven adept at board games like Chess and Go, reinforcement learning, has now been adapted for a powerful protein design program. The results show that reinforcement learning can do more than master board games. When trained to solve long-standing puzzles in protein science, the software excelled at creating useful molecules. In one experiment, proteins made with the new approach were found to be more effective at generating useful antibodies in mice than were previous methods. If this method is applied to the right research problems, it likely could accelerate progress in a variety of scientific fields.

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Evolution of two contagious cancers affecting Tasmanian devils underlines unpredictability of disease threat. Scientists have traced the family trees of two transmissible cancers that affect Tasmanian devils and have pinpointed mutations which may drive growth of deadly diseases.

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An essential pillar of Earth's ecological system, fungi have long been used to better the lives of humans. While these organisms are still vastly understudied, a new review paper suggests that their unique genomes could be used to make progress in the biotech industry.

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Scientists have made a remarkable discovery about cellophane bees -- their microbiomes are some of the most fermentative known from the insect world. These bees, which are named for their use of cellophane-like materials to line their subterranean nests, are known for their fascinating behaviors and their important ecological roles as pollinators. Now, researchers have uncovered another aspect of their biology that makes them even more intriguing.

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Marijuana (cannabis) is well known for giving people the 'munchies.' Not only does it make people want to eat more, but it also makes them crave the tastiest, most high-calorie foods. Now a new study shows that well-studied nematode worms (C. elegans) react to those chemicals known as cannabinoids in precisely the same way.

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A new machine-learning system can generate protein designs with certain structural features, and which do not exist in nature. These proteins could be utilized to make materials that have similar mechanical properties to existing materials, like polymers, but which would have a much smaller carbon footprint.

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Increased insect consumption by humans may be better for both gut health and planetary health. Chitin (kai'tin) and healthy fats from insects appear to contribute to healthy gut microbiota and are strong sources of protein and nutrients, according to a recent paper.