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Categories: Biology: Biotechnology
Published New discovery of a mechanism that controls cell division
(via sciencedaily.com) Original source Researchers have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of certain diseases.
Published Novel chemical tool for understanding membrane remodeling in the cell
(via sciencedaily.com) Original source Researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell. The findings lead to a deeper understanding of how membrane remodeling works in human cells and future development of new drugs.
Published Scientists track 'doubling' in origin of cancer cells
(via sciencedaily.com) Original source Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.
Published Deeper understanding of malaria parasite development unlocks opportunities to block disease spread
(via sciencedaily.com) Original source Natural malaria infections have been genetically analysed at a higher resolution than ever before, giving insights that could help understand and block transmission.
Published Promising new treatment strategy for deadly flu-related brain disorders
(via sciencedaily.com) Original source Researchers have found that a brain disorder associated with flu (influenza-associated encephalopathy, or IAE) can be caused by the influenza virus entering the brain from the blood via endothelial cells. In these cells, the researchers observed viral protein accumulation, suggesting that antivirals targeting viral transcription/translation may be useful treatments for some patients. Given the lack of effective treatments for IAE, this finding will likely improve patient care and reduce IAE-related deaths worldwide.
Published New approach in the synthesis of complex natural substances
(via sciencedaily.com) Original source Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.
Published Activation of innate immunity: Important piece of the puzzle identified
(via sciencedaily.com) Original source Researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.
Published Malaria may shorten leukocyte telomeres among sub-Saharan Africans
(via sciencedaily.com) Original source The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report. Moreover, leukocyte telomere length (LTL) is negatively associated with malaria endemicity and only partly explained by genetic factors.
Published Archaea can be picky parasites
(via sciencedaily.com) Original source A parasite that not only feeds of its host, but also makes the host change its own metabolism and thus biology. Microbiologists have shown this for the very first time in a specific group of parasitic microbes, so-called DPANN archea. Their study shows that these archaea are very 'picky eaters', which might drive their hosts to change the menu.
Published Key functions of therapeutically promising jumbo viruses
(via sciencedaily.com) Original source Viruses known as 'jumbo' phages are seen as a potential tool against deadly bacterial infections. But scientists must first decipher the extraordinary makeup of these mysterious viruses. Researchers have now uncovered a key piece of jumbo phage development that helps them counter bacteria.
Published Marriage of synthetic biology and 3D printing produces programmable living materials
(via sciencedaily.com) Original source Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.
Published Novel genetic plant regeneration approach without the application of phytohormones
(via sciencedaily.com) Original source Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner.
Published New and improved way to grow the cells that give rise to the kidney's filtration system
(via sciencedaily.com) Original source Scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney's filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. The team improved the chemical cocktail for generating and growing NPCs in the laboratory, enabling the sustained growth of both mouse and human NPCs in a simple 2-dimensional format.
Published Researchers parse oddity of distantly related bats in Solomon Islands that appear identical
(via sciencedaily.com) Original source A study of body size in leaf-nosed bats of the Solomon Islands has revealed surprising genetic diversity among nearly indistinguishable species on different islands.
Published Discovery of mechanism plants use to change seed oil could impact industrial, food oils
(via sciencedaily.com) Original source Researchers have discovered a new mechanism of oil biosynthesis and found a way to genetically engineer a type of test plant to more efficiently produce different kinds of seed oil that it otherwise wouldn't make. While the engineering is proof-of-concept, this discovery could lead to improved production of valuable oils used in food and by a range of industries. The modified plant overcame metabolic bottlenecks and produced significant amounts of an oil similar to castor oil that it doesn't naturally produce.
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases
(via sciencedaily.com) Original source The research explores how CRISPR can be used to edit RNA.
Published Study details a common bacterial defense against viral infection
(via sciencedaily.com) Original source Researchers report on the molecular assembly of one of the most common anti-phage systems -- from the family of proteins called Gabija -- that is estimated to be used by at least 8.5%, and up to 18%, of all bacteria species on Earth.
Published Curiosity promotes biodiversity
(via sciencedaily.com) Original source Cichlid fishes exhibit differing degrees of curiosity. The cause for this lies in their genes, as reported by researchers. This trait influences the cichlids' ability to adapt to new habitats.
Published With hybrid brains, these mice smell like a rat
(via sciencedaily.com) Original source Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.
Published Synthetic droplets cause a stir in the primordial soup
(via sciencedaily.com) Original source Our bodies are made up of trillions of different cells, each fulfilling their own unique function to keep us alive. How do cells move around inside these extremely complicated systems? How do they know where to go? And how did they get so complicated to begin with? Simple yet profound questions like these are at the heart of curiosity-driven basic research, which focuses on the fundamental principles of natural phenomena.