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Categories: Anthropology: Early Humans, Biology: Biotechnology

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Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Scientists are studying the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development.

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Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

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An obscure aquatic plant has helped to explain how plants avoid cracking up under the stresses and strains of growth.

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The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists.

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Engineers designed a technology to probe connections between the brain and the digestive tract. Using fibers embedded with a variety of sensors, as well as optogenetic stimulation, the researchers could control neural circuits connecting the gut and the brain, in mice.

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For the first time, researchers have developed a genome-scale way to map the regulatory role of transcription factors, proteins that play a key role in gene expression and determining a plant's physiological traits. Their work reveals unprecedented insights into gene regulatory networks and identifies a new library of DNA parts that can be used to optimize plants for bioenergy and agriculture.

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Fifteen years of archaeological work in the Tam Pa Ling cave in northeastern Laos has yielded a reliable chronology of early human occupation of the site. The team's excavations through the layers of sediments and bones that gradually washed into the cave and were left untouched for tens of thousands of years reveals that humans lived in the area for at least 70,000 years -- and likely even longer.

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Scientists have built a new, comprehensive AutoML platform designed for biologists with little to no ML experience. New automated machine learning platform enables easy, all-in-one analysis, design, and interpretation of biological sequences with minimal coding. Their platform, called BioAutoMATED, can use sequences of nucleic acids, peptides, or glycans as input data, and its performance is comparable to other AutoML platforms while requiring minimal user input.

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DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.

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Researchers have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer.

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Scientists have uncovered a new quality control system that removes damaged cells from early developing embryos.

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Researchers have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.

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Research sheds light on human evolution, and demonstrates an approach for identifying significant differences in how genes are used between closely-related species.

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In the face of the biodiversity crisis, and alarming data showing a 69% decline in global animal populations since 1970, researchers are banking on a cool solution to help save species from extinction. Much like egg-freezing is used to preserve human fertility options for a later date, the cryo-freezing of genetic samples taken from animals may play an essential role in curbing species extinctions. A new study sheds light on the immense potential of living cell banks, also known as cryobanks, to contribute to global conservation priorities.

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Genome Architecture Mapping captures complex, multi-way interactions in the genome. This is different than the workhorse technique of 3D genomics, which sees mostly two-way contacts, finds a new study.

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Scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.

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A team or researchers reports the first Aging Fly Cell Atlas (AFCA), a detailed characterization of the aging process in 163 distinct cell types in the laboratory fruit fly. Their in-depth analysis revealed that different cell types in the body age differently, each cell type following a process involving cell type-specific patterns. AFCA provides a valuable resource for researchers in the fruit fly and aging communities as a reference to study aging and age-related diseases and to evaluate the success of anti-aging strategies.

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Digital modelling of legendary fossil's soft tissue suggests Australopithecus afarensis had powerful leg and pelvic muscles suited to tree dwelling, but knee muscles that allowed fully erect walking.

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Researchers have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections. Their research findings can inform the development of future treatments for life-threatening acute infections.

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Hundreds of human skulls and mandibles recovered from the Crenshaw site in southwest Arkansas are the remains of ancestors of the Caddo Nation and not foreign enemies, according to a new study.