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Categories: Anthropology: Early Humans, Biology: Biotechnology

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Biochemists have succeeded in resurrecting the ancestral genes of five detoxifying enzymes which are present in all tetrapods to show how their divergence in function has occurred.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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Scientists who study the origins and evolution of the plague have examined hundreds of ancient human teeth from Denmark, seeking to address longstanding questions about its arrival, persistence and spread within Scandinavia.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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A new study explores 'balancing selection' by analyzing thousands of modern human genomes alongside ancient hominin groups, such as Neanderthal and Denisovan genomes. The research has 'implications for understanding human diversity, the origin of diseases, and biological trade-offs that may have shaped our evolution,' says evolutionary biologists.

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Along the shores of Africa's Lake Victoria in Kenya roughly 2.9 million years ago, early human ancestors used some of the oldest stone tools ever found to butcher hippos and pound plant material, according to new research. The study presents what are likely to be the oldest examples of a hugely important stone-age innovation known to scientists as the Oldowan toolkit, as well as the oldest evidence of hominins consuming very large animals. Excavations at the site, named Nyayanga and located on the Homa Peninsula in western Kenya, also produced a pair of massive molars belonging to the human species' close evolutionary relative Paranthropus. The teeth are the oldest fossilized Paranthropus remains yet found, and their presence at a site loaded with stone tools raises intriguing questions about which human ancestor made those tools.

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An interdisciplinary team of scientistshas found that rapid sea-level rise drove early settlers in Southeast Asia to migrate during the prehistoric period, increasing the genetic diversity of the region today.

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Seeking to better understand more about the origins and movement of bubonic plague, in ancient and contemporary times, researchers have completed a painstaking granular examination of hundreds of modern and ancient genome sequences, creating the largest analysis of its kind.

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The analysis of ancient DNA allows scientists to trace human evolution and make important discoveries about modern populations. The data revealed by ancient DNA sampling can be valuable, but the human remains that carry this ancient DNA are often those of the ancestors of modern Indigenous groups, and some communities have expressed concerns about the ethics of sampling by outside parties. A group of scientists make the case for involvement of descendant communities in all aspects of the research process.

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Smallpox was once one of humanity's most devastating diseases, but its origin is shrouded in mystery. For years, scientific estimates of when the smallpox virus first emerged have been at odds with historical records. Now, a new study reveals that the virus dates back 2,000 years further than scientists have previously shown, verifying historical sources and confirming for the first time that the disease has plagued human societies since ancient times.

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Using a new method based upon comparing DNA mutation rates between parents and offspring, evolutionary biologists have revealed the average age of mothers versus fathers over the past 250,000 years, including the discovery that the age gap is shrinking, with women's average age at conception increasing from 23.2 years to 26.4 years, on average, in the past 5,000 years.

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Archaeologists have uncovered projectile points in Idaho that are thousands of years older than any previously found in the Americas, helping to fill in the history of how early humans crafted and used stone weapons.

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Human bipedalism -- walking upright on two legs -- may have evolved in trees, and not on the ground as previously thought, according to a new study.

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Modern Papuans' immune system likely evolved with a little help from the Denisovans, a mysterious human ancestor who interbred with ancient humans, according to a new study.

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Agriculture is driving rapid evolutionary change, not just on farms but also in wild species in surrounding landscapes, new research has found.

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For over a century, one of the earliest human fossils ever discovered in Spain has been long considered a Neanderthal. However, new analysis from an international research team dismantles this century-long interpretation, demonstrating that this fossil is not a Neanderthal; rather, it may actually represent the earliest presence of Homo sapiens ever documented in Europe.

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Researchers have discovered and characterized a DNA sequence found in jawed vertebrates, such as sharks and humans, but absent in jawless vertebrates, such as lampreys. This DNA is important for the shaping of the joint surfaces during embryo development.