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Categories: Biology: Biotechnology, Space: Astrophysics

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Using cryo-electron microscopy (cryo-EM), researchers captured unprecedented images of key immune system receptors interacting with messenger proteins, elucidating how the receptors change shape upon activation and transmit signals within the cell. The findings suggest new pathways for developing therapeutic molecules for diseases such as COVID-19, rheumatoid arthritis, neurodegenerative diseases and cancer.

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The legendary Alexander Fleming, who famously discovered penicillin, once said 'never to neglect an extraordinary appearance or happening.' And the path of science often leads to just that. New research is turning the page in our understanding of harmful bacteria and how they turn on certain genes, causing disease in our bodies.

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In the world of threatened and endangered species conservation, the genomic revolution has raised some complicated questions: How can scientists justify assessing species genetic diversity without consulting entire genomes now that they can be sequenced? But then again, how can scientists justify the time and expense of genome sequencing when age-old measures of neutral genetic diversity are much cheaper and easier to obtain? A new study suggests making a transition from 'old school' genetics to 'new school' genomics for species conservation purposes probably isn't necessary in all cases.

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Researchers have discovered how the fungus Candida albicans enters the brain, activates two separate mechanisms in brain cells that promote its clearance, and, important for the understanding of Alzheimer's disease development, generates amyloid beta (Ab)-like peptides, toxic protein fragments from the amyloid precursor protein that are considered to be at the center of the development of Alzheimer's disease.

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A new article describes 'a missing law of nature,' recognizing for the first time an important norm within the natural world's workings.   In essence, the new law states that complex natural systems evolve to states of greater patterning, diversity, and complexity. In other words, evolution is not limited to life on Earth, it also occurs in other massively complex systems, from planets and stars to atoms, minerals, and more.

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A bacterium found in the sea can degrade a plastic that otherwise resists microbial breakdown in marine environments.

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The heat shock response of cells is a classic model of biological adaptation, part of the fundamental processes of life -- conserved in creatures from single-celled yeast to humans -- that allow our cells to adjust to changing conditions in their environment. For years, scientists have focused on how different genes respond to heat stress to understand this survival technique. Now, thanks to the innovative use of advanced imaging techniques, researchers are getting an unprecedented look at the inner machinery of cells to see how they respond to heat stress. 

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Fecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant. Most failures of fecal microbe transplantation occur in the first four weeks. Researchers have now found 19 Bacteroides vulgatus genes that were unique to three strains that show early engraftment in patients after a fecal transplant, as opposed to seven strains that did not show early engraftment.

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Researchers have extracted and analyzed DNA from fruit flies housed in museum collections in Lund, Stockholm and Copenhagen. Surprisingly, the researchers found the fruit flies collected in Sweden in the early 1800s were more genetically similar to 21st century flies than the Swedish samples from the 1930s.

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As part of the effort to better understand the evolution of the brains in people and animals, a research team has generated the world's largest primate brain-wide atlas.    

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A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain. This understanding of brain structure allows for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.

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Synthetic biologists report on a new approach to attacking tumors. They have engineered tumor-colonizing bacteria (probiotics) to produce synthetic targets in tumors that direct CAR-T cells to destroy the newly highlighted cancer cells.

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To study muscle diseases, scientists rely on the mouse as a model organism. Researchers have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers.

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One of the greatest strengths of NASA's James Webb Space Telescope is its ability to give astronomers detailed views of areas where new stars are being born. The latest example, showcased here in a new image from Webb's Mid-Infrared Instrument (MIRI), is NGC 346 -- the brightest and largest star-forming region in the Small Magellanic Cloud.

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Researchers have obtained new insights into how African-American and Hispanic-American people’s genes influence their ability to use Omega-3 and Omega-6 fatty acids for good health. The findings are an important step toward “precision nutrition” – where a diet tailored to exactly what our bodies need can help us live longer, healthier lives.

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DNA analysis of mummified feces reveals two pre-Columbian Caribbean cultures ate a wide variety of plants, like maize, sweet potato, and peanuts -- and tobacco and cotton traces were detected too, according to a new study.

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Evolutionary biologists have for the first time decoded the genetic lineage of a famous killer whale and a pod that once worked alongside whale hunters off the coast of Australia. In the Australian tradition of claiming New Zealand's celebrities as its own, Old Tom, the leader of a pod of killer whales that famously helped whalers hunt baleen whales in the 20th century, has ancestral links to modern-day killer whales in New Zealand, according to new DNA research. Old Tom also shared a common ancestor with killer whales from Australasia, the North Pacific, and North Atlantic Oceans, but is most similar to modern New Zealand killer whales. However, most of Tom's DNA code is not found in other killer whales globally suggesting that the killer whales of Eden may have become extinct locally.

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Fast radio bursts, or FRBs, are an astronomical mystery, with their exact cause and origins still unconfirmed. These intense bursts of radio energy are invisible to the human eye, but show up brightly on radio telescopes. Previous studies have noted broad similarities between the energy distribution of repeat FRBs, and that of earthquakes and solar flares. However, new research has looked at the time and energy of FRBs and found distinct differences between FRBs and solar flares, but several notable similarities between FRBs and earthquakes. This supports the theory that FRBs are caused by 'starquakes' on the surface of neutron stars. This discovery could help us better understand earthquakes, the behavior of high-density matter and aspects of nuclear physics.

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Though scientists have long known through observational data that the Milky Way is warped and its edges are flared like a skirt, no one could explain why. Now, astronomers have performed the first calculations that fully explain this phenomenon, with compelling evidence pointing to the Milky Way's envelopment in an off-kilter halo of dark matter. 

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An unexpectedly high number of young stars has been identified in the direct vicinity of a supermassive black hole and water ice has been detected at the center of our galaxy.