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Categories: Biology: Biotechnology, Space: Astrophysics

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Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.

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CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions.   While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.

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Researchers have rediscovered and successfully cultivating Rhabdamoeba marina -- a rare marine amoeba that has only been reported in two cases in the past century. Using this culture strain, they performed a comprehensive analysis of its genetic sequence, revealing for the first time the phylogenetic position of this enigmatic amoeba, and proposed a novel taxonomic classification based on their research findings.

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Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.

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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation.  Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.

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Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.

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Many mammals, from domestic cats and dogs to giant pandas, use scent to communicate with each other. A new study shows how domestic cats send signals to each other using odors derived from families of bacteria living in their anal glands. 

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Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.

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Researchers have unveiled a groundbreaking approach to label-free visualization of intracellular cargo trafficking in living cells, achieving high-speed and limitless observation capabilities. By developing a cargo-localization interferometric scattering (CL-iSCAT) microscope, scientists meticulously tracked the intricate movements of numerous cargos in the bustling cellular world. Surprisingly, cells employ human-like strategies to manage their transport challenges.

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ALMA (Atacama Large Millimeter/submillimeter Array) has demonstrated the highest resolution yet with observations of an old star. The observations show that the star is surrounded by a ring-like structure of gas and that gas from the star is escaping to the surrounding space. Future observations with the newly demonstrated high resolution are expected to elucidate, not only the end of a star's life, but also the beginning, when planets are still forming.

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Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.

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After a distant star's explosive death, an active stellar corpse was the likely source of repeated energetic flares observed over several months -- a phenomenon astronomers had never seen before, astronomers report.

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Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles. 

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Data from a NASA mission to map dark matter around galaxy clusters has been saved by a new recovery system. The system allowed the retrieval of gigabytes of information, even after communication failed and the balloon-based telescope was damaged in the landing process.

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How did the molecular building blocks for life end up on Earth? One long-standing theory is that they could have been delivered by comets. Now, researchers have shown how comets could deposit similar building blocks to other planets in the galaxy.

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Chemists have developed a new tool for detecting interactions between sugars and lectins, a discovery that could help in the fight against diseases like cancer.

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The one thing everyone knows about black holes is that absolutely everything nearby gets sucked into them. Almost everything, it turns out. Astrophysicists have now determined conclusively that energy close to the event horizon of black hole M87* is pushing outward, not inward. The researchers have also created a way to test the prediction that black holes lose rotational energy and to establish it's that energy that produces the incredibly powerful jets.

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Rhomboid-like protein 10, or RBL10, is thought to be an enzyme that degrades other proteins in the chloroplast membrane, but its function is largely unknown. Researchers are studying how RBL10 affects photosynthetic membrane lipid metabolism, an essential process in photosynthesis.

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Astronomers have detailed radio observations of an extraordinary aurora-like display -- occurring 40,000 km above a relatively dark and cold patch on the Sun, known as a sunspot.

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An international research team has made an unexpected discovery of a biased counting mechanism used by the single-celled green alga Chlamydomonas to control cell division.