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Categories: Biology: Biotechnology, Space: Astrophysics
Published Largest-ever map of universe's active supermassive black holes released
(via sciencedaily.com) Original source Astronomers have charted the largest-ever volume of the universe with a new map of active supermassive black holes living at the centers of galaxies. Called quasars, the gas-gobbling black holes are, ironically, some of the universe's brightest objects. The new map logs the location of about 1.3 million quasars in space and time, the furthest of which shone bright when the universe was only 1.5 billion years old. The work could help scientists better understand the properties of dark matter.
Published How cells are ahead of the curve
(via sciencedaily.com) Original source The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.
Published Engineers measure pH in cell condensates
(via sciencedaily.com) Original source In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.
Published DNA origami-based vaccines toward safe and highly-effective precision cancer immunotherapy
(via sciencedaily.com) Original source Researchers have created a DNA origami platform called DoriVac, whose core component is a self-assembling square block-shaped nanostructure. DoriVac vaccines enabled tumor-bearing mice to better control the growth of tumors and to survive significantly longer than control mice.
Published New research suggests that our universe has no dark matter
(via sciencedaily.com) Original source A new study challenges the current model of the universe by showing that, in fact, it has no room for dark matter.
Published Protein fragments ID two new 'extremophile' microbes--and may help find alien life
(via sciencedaily.com) Original source Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.
Published Breakthrough could make automated dosing systems universal
(via sciencedaily.com) Original source Automated insulin dosing systems combine low-cost blood-glucose monitors with insulin pumps that use precision dosing to continuously regulate blood-sugar and hold it steady. Synthetic biologists have found a way to piggyback on the technology and make it universally applicable for the precision dosing of virtually any drug.
Published New study on mating behaviors offers clues into the evolution of attraction
(via sciencedaily.com) Original source In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.
Published It's hearty, it's meaty, it's mold
(via sciencedaily.com) Original source Scientists are exploring how tuning the genomes of mushrooms and molds can transform these food sources into gourmet, nutrient-packed meals made with minimal processing and a light environmental footprint.
Published Alzheimer's drug fermented with help from AI and bacteria moves closer to reality
(via sciencedaily.com) Original source Researchers combined artificial intelligence and chemical biosensors to ferment the precursor of an Alzheimer's drug in bacteria.
Published New bioengineered protein design shows promise in fighting COVID-19
(via sciencedaily.com) Original source A recent scientific breakthrough has emerged from the work of researchers aiming to combat SARS-CoV-2, the virus responsible for COVID-19. The study focuses on the design and development of a novel protein capable of binding to the spike proteins found on the surface of the coronavirus. The goal behind this innovative approach is twofold: first, to identify and recognize the virus for diagnostic purposes, and second, to hinder its ability to infect human cells.
Published Even cells know the importance of recycling
(via sciencedaily.com) Original source Researchers uncovered the mechanistic details behind how several proteins interact to help cells recognize and remove damaged mitochondria. Optineurin (OPTN) and its interactions are needed to provide a contact site for another protein, Tank-binding kinase 1 (TBK1), during this process. The OPTN-TBK1 relationship is necessary for these mitochondria to be recognized and eliminated from the cell. This mechanism may have relevance for developing drugs to treat Parkinson's disease.
Published New simpler and cost-effective forensics test helps identify touch DNA
(via sciencedaily.com) Original source Research has found a less expensive and easier to use test to learn more about forensic touch DNA. This research has important implications for forensic investigations and being able to identify DNA from a primary contact -- someone who may have committed the crime -- as well as secondary DNA that was inadvertently and indirectly transferred through touch.
Published Cheers! NASA's Webb finds ethanol, other icy ingredients for worlds
(via sciencedaily.com) Original source What do margaritas, vinegar, and ant stings have in common? They contain chemical ingredients that NASA's James Webb Space Telescope has identified surrounding two young protostars known as IRAS 2A and IRAS 23385. Although planets are not yet forming around those stars, these and other molecules detected there by Webb represent key ingredients for making potentially habitable worlds.
Published Explaining a supernova's 'string of pearls'
(via sciencedaily.com) Original source Physicists often turn to the Rayleigh-Taylor instability to explain why fluid structures form in plasmas, but that may not be the full story when it comes to the ring of hydrogen clumps around supernova 1987A, research suggests. It looks like the same mechanism that breaks up airplane contrails might be at play in forming the clumps of hydrogen gas that ring the remnant of supernova 1987A.
Published Steroid drugs used for HRT can combat E. coli and MRSA
(via sciencedaily.com) Original source Researchers have combined computational and microbiology laboratory approaches to identify existing drugs that can be repurposed to combat antibiotic-resistant bacterial infections. This research has revealed that a class of steroid drugs currently used in hormone replacement therapy (HRT) can also stop the growth of antibiotic-resistant E. coli and effectively kill MRSA.
Published New computational strategy boosts the ability of drug designers to target proteins inside the membrane
(via sciencedaily.com) Original source Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new custom-designed proteins that can efficiently reach these 'intramembrane' targets.
Published Simple trick could improve accuracy of plant genetics research
(via sciencedaily.com) Original source Researchers have published a simple trick that improves the accuracy of techniques that help us understand how external variables -- such as temperature -- affect gene activity in plants.
Published Milk to the rescue for diabetics? Cow produces human insulin in milk
(via sciencedaily.com) Original source An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.
Published A simple and robust experimental process for protein engineering
(via sciencedaily.com) Original source A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study.