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Categories: Biology: Biotechnology, Space: Astrophysics

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Naloxone -- a fast-acting opioid antidote -- has saved lives, but it's less effective against powerful synthetic opioids, such as fentanyl. In an interesting twist, researchers are now investigating cannabidiol (CBD), a component of marijuana, as a possible alternative to the popular antidote. Today, a team reports compounds based on CBD that reduce fentanyl binding and boost the effects of naloxone.

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Researchers discover that actin acts in the cell nucleus and is partly responsible for the expression of male sexual characteristics.

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Free-range organic chicken or factory farming? Scientists have developed a new detection method that can reveal such differences in husbandry. The so-called epigenetic method is based on the analysis of the characteristic patterns of chemical markers on the genome of the animals.

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With CRISPR-Cas9 technology, humans can now rapidly change the evolutionary course of animals or plants by inserting genes that can easily spread through entire populations. An evolutionary geneticist proposes that we call this evolutionary meddling 'genetic welding.' He argues that we must scientifically and ethically scrutinize the potential consequences of genetic welding before we put it into practice.

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A team of scientists designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

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Astronomers have found the atmospheric compositions of giant planets out in the galaxy do not fit our own solar system trend.

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An international team of researchers has used NASA's James Webb Space Telescope to measure the temperature of the rocky exoplanet TRAPPIST-1 b. The measurement is based on the planet's thermal emission: heat energy given off in the form of infrared light detected by Webb's Mid-Infrared Instrument (MIRI). The result indicates that the planet's dayside has a temperature of about 500 kelvins (roughly 450 degrees Fahrenheit) and suggests that it has no significant atmosphere.

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To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team of scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.

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Squids and octopuses are masters of camouflage. But some aspects of how they become reversibly transparent are still 'unclear,' because researchers can't culture cephalopod skin cells in the lab. Now, researchers have replicated the tunable transparency of squid skin in mammalian cells, which are more easily cultured.

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Researchers have developed a hybrid micro-robot, the size of a single biological cell (about 10 microns across), that can be controlled and navigated using two different mechanisms -- electric and magnetic. The micro-robot is able to navigate between different cells in a biological sample, distinguish between different types of cells, identify whether they are healthy or dying, and then transport the desired cell for further study, such as genetic analysis.

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A parasite which has devastating impacts on agriculture and human health is the first pathogen to have its proteins located and mapped within its cells -- providing clues to their function and helping to identify potential drug targets.

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Researchers have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB. If this natural process can be harnessed with new treatments, it could present an alternative to, or improve use of antibiotics, especially where bacteria have become resistant to existing drugs.

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Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the activation of all available repair mechanisms. A research team has now shown that normal body cells can also be repaired better once this complex has been deactivated. In the long run, the scientists hope to develop better therapies to prevent cancer and aging-associated diseases.

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Astrophysicists have leveraged artificial intelligence to uncover a better way to estimate the mass of colossal clusters of galaxies. The AI discovered that by just adding a simple term to an existing equation, scientists can produce far better mass estimates than they previously had. The improved estimates will enable scientists to calculate the fundamental properties of the universe more accurately, the astrophysicists have reported.

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Machine learning and state-of-the-art supernova nucleosynthesis has helped researchers find that the majority of observed second-generation stars in the universe were enriched by multiple supernovae.

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Scientists have significantly advanced the race to control plant responses to temperature on a rapidly warming planet. Key to this breakthrough is miRNA, a molecule nearly 200,000 times smaller than the width of a human hair.

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Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. Researchers have now described a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans. These effector memory B cells appear to be poised for a rapid serum antibody response upon secondary challenge one year later.

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When the first interstellar comet ever seen in our solar system was discovered in 2017, one characteristic -- an unexplained acceleration away from the sun -- sparked wild speculation, including that it was an alien spacecraft. An astrochemist found a simpler explanation and tested it with an astronomer: in interstellar space, cosmic rays converted water to hydrogen in the comet's outer layers. Nearing the sun, outgassed hydrogen gave the tiny comet a kick.

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Physicists have detected neutrinos created by a particle collider. The discovery promises to deepen scientists' understanding of the subatomic particles, which were first spotted in 1956 and play a key role in the process that makes stars burn.

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Researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.