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Categories: Biology: Biotechnology, Space: Astrophysics
Published Scientists create CRISPR-based drug candidate targeting the microbiome
(via sciencedaily.com) Original source A new drug candidate targeting E. coli in the gut is in phase 1 clinical trials. According to a new paper it may improve the well-being of blood cancer patients and reduce their mortality rate from E. coli infections.
Published 'Super-resolution' imaging technology
(via sciencedaily.com) Original source Researchers describe developing a super-resolution imaging platform technology to improve understanding of how nanoparticles interact within cells.
Published Scientists develop gene silencing DNA enzyme that can target a single molecule
(via sciencedaily.com) Original source Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Published Galactic bubbles are more complex than imagined
(via sciencedaily.com) Original source Astronomers have revealed new evidence about the properties of the giant bubbles of high-energy gas that extend far above and below the Milky Way galaxy's center.
Published T cells can activate themselves to fight tumors
(via sciencedaily.com) Original source Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.
Published New probe aids novel findings on cell functions
(via sciencedaily.com) Original source New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.
Published An unprecedented view of gene regulation
(via sciencedaily.com) Original source Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
Published Tiny microbes could brew big benefits for green biomanufacturing
(via sciencedaily.com) Original source Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.
Published Gutless marine worms on a Mediterranean diet: Animals can synthesize phytosterols
(via sciencedaily.com) Original source Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.
Published Alternative 'fuel' for string-shaped motors in cells
(via sciencedaily.com) Original source Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.
Published Neutron star's X-rays reveal 'photon metamorphosis'
(via sciencedaily.com) Original source A 'beautiful effect' predicted by quantum electrodynamics (QED) can explain the puzzling first observations of polarized X-rays emitted by a magnetar -- a neutron star featuring a powerful magnetic field, according to an astrophysicist.
Published Astronomers spot a star swallowing a planet
(via sciencedaily.com) Original source Scientists have observed a star swallowing a planet for the first time. Earth will meet a similar fate in 5 billion years.
Published Scientists recover an ancient woman's DNA from a 20,000-year-old pendant
(via sciencedaily.com) Original source An international research team has for the first time successfully isolated ancient human DNA from a Paleolithic artefact: a pierced deer tooth discovered in Denisova Cave in southern Siberia. To preserve the integrity of the artefact, they developed a new, nondestructive method for isolating DNA from ancient bones and teeth. From the DNA retrieved they were able to reconstruct a precise genetic profile of the woman who used or wore the pendant, as well as of the deer from which the tooth was taken. Genetic dates obtained for the DNA from both the woman and the deer show that the pendant was made between 19,000 and 25,000 years ago. The tooth remains fully intact after analysis, providing testimony to a new era in ancient DNA research, in which it may become possible to directly identify the users of ornaments and tools produced in the deep past.
Published Astronomers find distant gas clouds with leftovers of the first stars
(via sciencedaily.com) Original source Using ESO's Very Large Telescope (VLT), researchers have found for the first time the fingerprints left by the explosion of the first stars in the Universe. They detected three distant gas clouds whose chemical composition matches what we expect from the first stellar explosions. These findings bring us one step closer to understanding the nature of the first stars that formed after the Big Bang.
Published A novel stem cell adhesive using mussels
(via sciencedaily.com) Original source A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.
Published Chances of eliminating HIV infection increased by novel dual gene-editing approach
(via sciencedaily.com) Original source Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
Published Scientists present evidence for a billion-years arms race between viruses and their hosts
(via sciencedaily.com) Original source Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.
Published A stormy, active sun may have kickstarted life on Earth
(via sciencedaily.com) Original source The first building blocks of life on Earth may have formed thanks to eruptions from our Sun, a new study finds. A series of chemical experiments show how solar particles, colliding with gases in Earth's early atmosphere, can form amino acids and carboxylic acids, the basic building blocks of proteins and organic life.