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Categories: Biology: Biotechnology, Mathematics: Statistics
Published Syphilis-like diseases were widespread in Americas before arrival of Columbus, researchers find
(via sciencedaily.com) Original source Researchers have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago. This is the oldest verified discovery of this pathogen thus far, and it proves that humans were suffering from diseases akin to syphilis -- known as treponematoses -- long before Columbus's discovery of America. The new findings call into question previous theories concerning the spread of syphilis by the Spanish conquistadors.
Published New study unveils how plants control the production of reactive oxygen species
(via sciencedaily.com) Original source Reactive oxygen species (ROS), though generally regarded as toxic byproducts of biological processes, serve many important functions in plants. However, the precise mechanism that plants use to regulate the production of ROS remains elusive. In a recent study, researchers clarified how an important ROS-generating enzyme is activated, revealing mechanisms likely conserved across all land plants. Their findings could pave the way for breakthroughs in agricultural and environmental remediation tools.
Published Health researchers develop software to predict diseases
(via sciencedaily.com) Original source IntelliGenes analyzes genomic data to discover biomarkers associated with health traits.
Published New research guides mathematical model-building for gene regulatory networks
(via sciencedaily.com) Original source A newly published study provides guidance for building accurate mathematical models for gene regulatory networks.
Published Tiny worm, giant leap: Discovery of highly specific fatty acid attachment to proteins
(via sciencedaily.com) Original source In a world where the intricacies of molecular biology often seem as vast and mysterious as the cosmos, a new groundbreaking study delves into the microscopic universe of proteins, unveiling a fascinating aspect of their existence. This revelation could hold profound implications for the understanding and treatment of a myriad of human diseases.
Published Don't overeat: How archaea toggle the nitrogen-uptake switch
(via sciencedaily.com) Original source By tightly regulating nitrogen uptake, microorganisms avoid overeating nitrogen and thus wasting energy. Scientists now reveal how some methanogenic archaea manage to do so.
Published DNA construction led to unexpected discovery of important cell function
(via sciencedaily.com) Original source Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.
Published Ancient 'chewing gum' reveals stone age diet
(via sciencedaily.com) Original source What did people eat on the west coast of Scandinavia 10,000 years ago? A new study of the DNA in a chewing gum shows that deer, trout and hazelnuts were on the diet. It also shows that one of the individuals had severe problems with her teeth.
Published Nearly dead plants brought back to life: Keys to aging hidden in the leaves
(via sciencedaily.com) Original source Scientists have known about a particular organelle in plant cells for over a century. However, scientists have only now discovered that organelle's key role in aging.
Published Study throws our understanding of gene regulation for a loop
(via sciencedaily.com) Original source To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.
Published Machine learning reveals sources of heterogeneity among cells in our bodies
(via sciencedaily.com) Original source A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.
Published Glowing COVID-19 diagnostic test prototype produces results in one minute
(via sciencedaily.com) Original source Cold, flu and COVID-19 season brings that now-familiar ritual: swab, wait, look at the result. But what if, instead of taking 15 minutes or more, a test could quickly determine whether you have COVID-19 with a glowing chemical? In a new study, researchers describe a potential COVID-19 test inspired by bioluminescence. Using a molecule found in crustaceans, they have developed a rapid approach that detects SARS-CoV-2 protein comparably to one used in vaccine research.
Published Unraveling the role of supersulfides in regulating mitochondrial function and longevity
(via sciencedaily.com) Original source Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced supersulfide are unclear. Now, using a strategically engineered yeast mutant with a deficient CARS gene, researchers from Japan have shown that supersulfides control cell longevity by mediating mitochondrial energy metabolism and regulating protein quality.
Published Bioinformatics: Researchers develop a new machine learning approach
(via sciencedaily.com) Original source To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.
Published A novel pathway regulating lipid biosynthesis by fatty acids
(via sciencedaily.com) Original source Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis process of fatty acid in the liver is activated by saturated fatty acids and inhibited by polyunsaturated fatty acids, providing new insights into the intricate workings of this cleavage system.
Published 3D in vitro human atherosclerosis model for high-throughput drug screening
(via sciencedaily.com) Original source A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.
Published Researchers create light-powered yeast, providing insights into evolution, biofuels, cellular aging
(via sciencedaily.com) Original source Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.
Published New rice lines for Africa offer virus protection
(via sciencedaily.com) Original source The so-called Rice Yellow Mottle Virus (for short: RYMV) is responsible for high crop losses in Africa, particularly among small-scale farmers. A research team has now produced rice lines that are resistant to the disease by means of genome editing. The rice varieties are a preliminary step toward being able to generate resistant locally adapted elite varieties for small-scale food producers in Africa.
Published Spying on a shape-shifting protein
(via sciencedaily.com) Original source Researchers are using crystallography to gain a better understanding of how proteins shapeshift. The knowledge can provide valuable insight into stopping and treating diseases.
Published Clinical predictive models created by AI are accurate but study-specific, researchers find
(via sciencedaily.com) Original source Scientists were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. However, the models are highly context-dependent and cannot be generalized.