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Categories: Biology: Biotechnology, Space: Astronomy

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An AI strategy proven adept at board games like Chess and Go, reinforcement learning, has now been adapted for a powerful protein design program. The results show that reinforcement learning can do more than master board games. When trained to solve long-standing puzzles in protein science, the software excelled at creating useful molecules. In one experiment, proteins made with the new approach were found to be more effective at generating useful antibodies in mice than were previous methods. If this method is applied to the right research problems, it likely could accelerate progress in a variety of scientific fields.

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An essential pillar of Earth's ecological system, fungi have long been used to better the lives of humans. While these organisms are still vastly understudied, a new review paper suggests that their unique genomes could be used to make progress in the biotech industry.

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Investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.

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What if, by adding a couple of cell layers inside a corn kernel, the grain could become significantly richer in essential nutrients like iron, zinc, and protein? Such an improvement could benefit people who rely on corn for a large portion of their diet, as in many parts of the global south.

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Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.

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Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei. DNA tension plays a surprising role in this. Nanoscientists now publish how they have visualized this.

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A hitherto unknown mechanism for DNA folding is described in a new study. The findings provide new insights into chromosomal processes that are vital to both normal development and to prevent disease.

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Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases. This has led to a growing demand for selective, efficient, and safe ways of delivering siRNA in cells. Now, in a cooperation between the Universities of Amsterdam and Leiden, researchers have developed dedicated molecular nanocages for siRNA delivery. In a paper just out in the Journal Chem they present nanocages that are easy to prepare and display tuneable siRNA delivery characteristics.

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Plants that glow under ultraviolet (UV) light aren't only a figment of science fiction TV and movies. Roots of a traditional medicine plant called the orange climber, or Toddalia asiatica, can fluoresce an ethereal blue hue. And now, researchers have identified two coumarin molecules that could be responsible. These natural coumarins have unique fluorescent properties, and one of the compounds could someday be used for medical imaging.

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It looks like a black hole and bends light like a black hole, but it could actually be a new type of star. Though the mysterious object is a hypothetical mathematical construction, new simulations by Johns Hopkins researchers suggest there could be other celestial bodies in space hiding from even the best telescopes on Earth.

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A star's chemical composition strongly influences the ultraviolet radiation it emits into space and thus the conditions for the emergence of life in its neighborhood.

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Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works. The scientists applied their new method to control the glow of a green fluorescent protein derived from Japanese eel muscle.

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Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals. Researchers identified expression of the gene, Arrdc5, in the testicular tissue of mice, pigs, cattle and humans. When they knocked out the gene in mice, it created infertility only in the males, impacting their sperm count, movement and shape.

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An international team of astronomers announced the first exoplanet discovered through a combined approach of direct imaging and precision measurements of a star's motion on the sky. This new method promises to improve the efficiency of exoplanet searches, paving the way for the discovery of an Earth twin.

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Researchers describe how the Epstein-Barr virus exploits genomic weaknesses to cause cancer while reducing the body's ability to suppress it.

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Astronomers report the first exoplanet jointly discovered through direct imaging and precision astrometry, a new indirect method that identifies a planet by measuring the position of the star it orbits. Data from the Subaru Telescope in Hawai`i and space telescopes from the European Space Agency (ESA) were integral to the team's discovery.

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Pollinators such as honeybees produce special enzymes that detoxify defence chemicals produced by plants, new research shows.

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The iconic image of the supermassive black hole at the center of M87 has gotten its first official makeover based on a new machine learning technique called PRIMO. The team used the data achieved the full resolution of the array.

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Origin-of-life chemists propose that glyoxylate could have been the original source of sugars on the 'prebiotic' Earth

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From Earth, giant elliptical galaxies resemble highly symmetric blobs, but what's their real 3D structure? Astronomers have assembled one of the first 3D views of a giant elliptical galaxy, M87, whose central supermassive black hole has already been imaged by the Event Horizon Telescope. M87 turns out to be triaxial, like a potato. The revised view provides a more precise measure of the mass of the central black hole: 5.37 billion solar masses.