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Categories: Biology: Biotechnology, Engineering: Biometric
Published Tiny microbes could brew big benefits for green biomanufacturing
(via sciencedaily.com) Original source Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.
Published Gutless marine worms on a Mediterranean diet: Animals can synthesize phytosterols
(via sciencedaily.com) Original source Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.
Published Alternative 'fuel' for string-shaped motors in cells
(via sciencedaily.com) Original source Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.
Published Scientists recover an ancient woman's DNA from a 20,000-year-old pendant
(via sciencedaily.com) Original source An international research team has for the first time successfully isolated ancient human DNA from a Paleolithic artefact: a pierced deer tooth discovered in Denisova Cave in southern Siberia. To preserve the integrity of the artefact, they developed a new, nondestructive method for isolating DNA from ancient bones and teeth. From the DNA retrieved they were able to reconstruct a precise genetic profile of the woman who used or wore the pendant, as well as of the deer from which the tooth was taken. Genetic dates obtained for the DNA from both the woman and the deer show that the pendant was made between 19,000 and 25,000 years ago. The tooth remains fully intact after analysis, providing testimony to a new era in ancient DNA research, in which it may become possible to directly identify the users of ornaments and tools produced in the deep past.
Published A novel stem cell adhesive using mussels
(via sciencedaily.com) Original source A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.
Published Chances of eliminating HIV infection increased by novel dual gene-editing approach
(via sciencedaily.com) Original source Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
Published Scientists present evidence for a billion-years arms race between viruses and their hosts
(via sciencedaily.com) Original source Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.
Published Wiggly proteins guard the genome
(via sciencedaily.com) Original source Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.
Published Herpes study adds to understanding of viral reinfections, how to potentially prevent them
(via sciencedaily.com) Original source A new study on herpes infections of the eye helps shed light on the question of viral reinfections by identifying a key protein involved in viral reinfections that could be targeted by antiviral drugs.
Published Scientists identify antivirals that could combat emerging infectious diseases
(via sciencedaily.com) Original source A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.
Published Scientists slow aging by engineering longevity in cells
(via sciencedaily.com) Original source Researchers have developed a biosynthetic 'clock' that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Published Pulling the plug on viral infections: CRISPR isn't just about cutting
(via sciencedaily.com) Original source CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses. A new study reveals a previously unrecognized player in one such system -- a membrane protein that enhances anti-viral defense. According to study authors, the finding upends the idea that CRISPR systems mount their defense only by degrading RNA and DNA in cells.
Published Information 'deleted' from the human genome may be what made us human
(via sciencedaily.com) Original source What the human genome is lacking compared with the genomes of other primates might have been as crucial to the development of humankind as what has been added during our evolutionary history, according to a new study led by researchers at Yale and the Broad Institute of MIT and Harvard. The new findings, published April 28 in the journal Science, fill an important gap in what is known about historical changes to the human genome.
Published Mammalian evolution provides hints for understanding the origins of human disease
(via sciencedaily.com) Original source Even though it is important to know where these variations are located in the genome, it's also useful to know how or why these genetic variations happened in the first place.
Published Maths unlocks molecular interactions that open window to how life evolved
(via sciencedaily.com) Original source Landmark research by mathematicians sets out the definitive picture of biological adaptation at the level of intermolecular interactions.
Published New findings indicate gene-edited rice might survive in Martian soil
(via sciencedaily.com) Original source New research suggests future Martian botanists may be able to grow gene-edited rice on Mars.
Published Near-universal T cell immunity towards a broad range of bacteria
(via sciencedaily.com) Original source Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity. Scientists have discovered an exception to this rule. Namely, a group of divergent bacterial pathogens, including pneumococci, all share a small highly conserved protein sequence, which is both presented and recognized by human T cells in a conserved population-wide manner.
Published Ocean ecosystem: Mixotrophic microorganisms play key role
(via sciencedaily.com) Original source Researchers have identified a previously unknown group of bacteria, called UBA868, as key players in the energy cycle of the deep ocean. They are significantly involved in the biogeochemical cycle in the marine layer between 200 and 1000 meters.