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Categories: Biology: Biotechnology, Engineering: Biometric
Published Researchers to study Alzheimer's disease in marmosets
(via sciencedaily.com) Original source Neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmosets to accelerate the pace of drug discovery and rebuild the foundation for future translational studies.
Published New ribozyme can make RNA molecules accessible for click chemistry in living cells
(via sciencedaily.com) Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells.
Published 3D-printed 'living material' could clean up contaminated water
(via sciencedaily.com) A 'living material,' made of a natural polymer combined with genetically engineered bacteria, could offer a sustainable and eco-friendly solution to clean pollutants from water. Researchers developed their living material using a seaweed-based polymer and bacteria that have been programmed to produce an enzyme that transforms various organic pollutants into harmless compounds. In tests, heir material decontaminated water solutions tainted with a pollutant from textile manufacturing: indigo carmine, a blue dye that is used to color denim.
Published Red blood cells exposed to oxygen deficiency protect against myocardial infarction
(via sciencedaily.com) Original source Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new study. The study also shows that the protective effect is enhanced by a nitrate-rich vegetable diet.
Published Mutation rates in whales are much higher than previously reported
(via sciencedaily.com) Original source An international team of marine scientists has studied the DNA of family groups from four different whale species to estimate their mutation rates. Using the newly determined rates, the group found that the number of humpback whales in the North Atlantic before whaling was 86 percent lower than earlier studies suggested.
Published Newly discovered fungus helps destroy a harmful food toxin
(via sciencedaily.com) Original source Patulin is a harmful mycotoxin produced by fungi typically found in damaged fruits, including apples, pears, and grapes. In a recent breakthrough, researchers identified a new filamentous fungal strain that can degrade patulin by transforming it into less toxic substances. Their findings provide important insights into the degradation mechanisms for patulin found in nature, and can lead to new ways of controlling patulin toxicity in our food supplies.
Published The search for the super potato
(via sciencedaily.com) Original source As climate change continues to pose severe challenges to ensuring sustainable food supplies around the world, scientists are looking for ways to improve the resilience and nutritional quality of potatoes. Scientists have assembled the genome sequences of nearly 300 varieties of potatoes and its wild relatives to develop more nutritious, disease-free, and weather-proof crop. A team has now created a potato super pangenome to identify genetic traits that can help produce the next super spud.
Published How some ion channels form structures permitting drug delivery
(via sciencedaily.com) Original source A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.
Published Inhalable molecules neutralize SARS-CoV-2 in mice, study finds
(via sciencedaily.com) Original source Nanofitins, which are derived from a protein in an archaeal microorganism found in hot springs -- successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, the engineered nanofitins, which inhibit the virus by binding to its spike proteins, were observed to quickly reach the lungs in high doses both preventing and clearing early infections, researchers report.
Published New 'droplet battery' could pave the way for miniature bio-integrated devices
(via sciencedaily.com) Researchers have developed a miniature battery that could be used to power tiny devices integrated into human tissues. The design uses an ionic gradient across a chain of droplets -- inspired by how electric eels generate electricity. The device was able to regulate the biological activity of human neurons. This could open the way to the development of tiny bio-integrated devices, with a range of applications in biology and medicine.
Published Newly engineered versions of bacterial enzyme reveal how antibiotics could be more potent
(via sciencedaily.com) Original source Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).
Published Enhancing cancer therapy using functionalized photosynthetic bacteria
(via sciencedaily.com) Original source Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action.
Published Scientists invent new way to sort cells by type using light
(via sciencedaily.com) Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.
Published Unlocking the secrets of cell antennas
(via sciencedaily.com) Original source The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.
Published Pros and cons of ChatGPT plugin, Code Interpreter, in education, biology, health
(via sciencedaily.com) Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders.
Published Epigenetic mechanism that causes bitter taste distortion discovered
(via sciencedaily.com) Original source A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.
Published Researchers describe rebuilding, regenerating lung cells
(via sciencedaily.com) Original source Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.
Published The 'treadmill conveyor belt' ensuring proper cell division
(via sciencedaily.com) Original source Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.
Published Longevity gene from naked mole rats extends lifespan of mice
(via sciencedaily.com) Original source In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.
Published Biologist gets the scoop on squash bug poop
(via sciencedaily.com) Original source A discovery about how a common insect acquires a microbe that is essential for its growth may help in the control of an agricultural pest.