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Categories: Biology: Biotechnology, Engineering: Biometric
Published New computational strategy boosts the ability of drug designers to target proteins inside the membrane
(via sciencedaily.com) Original source Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new custom-designed proteins that can efficiently reach these 'intramembrane' targets.
Published Simple trick could improve accuracy of plant genetics research
(via sciencedaily.com) Original source Researchers have published a simple trick that improves the accuracy of techniques that help us understand how external variables -- such as temperature -- affect gene activity in plants.
Published Milk to the rescue for diabetics? Cow produces human insulin in milk
(via sciencedaily.com) Original source An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.
Published A simple and robust experimental process for protein engineering
(via sciencedaily.com) Original source A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study.
Published How a natural compound from sea squirts combats cancer
(via sciencedaily.com) Original source Trabectedin, a promising drug derived from the sea squirt Ecteinascidia turbinata, has shown potential in combating cancers resistant to conventional treatments. However, its precise mechanism of action has remained elusive -- until now.
Published Gene flow in giraffes and what it means for their conservation
(via sciencedaily.com) Original source Giraffes, with their bizarre body plan, have always held a special place in the minds of evolutionary biologists and non-experts alike. In a new study whole-genome sequencing data was used to investigate the evolutionary processes occurring within giraffes. In particular, the authors were interested in establishing whether different populations of giraffes really have been isolated from each other for extended periods of time, which is normally a requirement before new species can arise.
Published Study illuminates the protective role of fluorescence in neon-colored sea anemones
(via sciencedaily.com) Original source A team of researchers has uncovered a direct genetic link between fluorescence and color in sea anemones -- those soft and tentacled tide pool creatures often encountered by beachgoers.
Published New study reveals transgenerational effects of pesticide linuron on frogs
(via sciencedaily.com) Original source Grand-offspring of male frogs exposed to the pesticide linuron exhibited changes in their DNA that was linked to significant physiological impacts, a study reveals. The research highlights the profound transgenerational consequences of environmental pollution on amphibian populations, which are already under threat of extinction.
Published Unveiling Inaoside A: An antioxidant derived from mushrooms
(via sciencedaily.com) Original source Natural products have unique chemical structures and biological activities and can play a pivotal role in advancing pharmaceutical science. In a pioneering study, researchers discovered Inaoside A, an antioxidant derived from Laetiporus cremeiporus mushrooms. This breakthrough sheds light on the potential of mushrooms as a source of therapeutic bioactive compounds.
Published Anemonefish are better taxonomists than humans
(via sciencedaily.com) Original source Scientists reveal new lineages of giant sea anemones in Japan and their surprising associations with anemonefish.
Published Research sheds light on new strategy to treat infertility
(via sciencedaily.com) Original source New research describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. The technique could be used by women of advanced maternal age or for those who are unable to produce viable eggs due to previous treatment for cancer or other causes. It also raises the possibility of men in same-sex relationships having children who are genetically related to both parents.
Published New study discovers how altered protein folding drives multicellular evolution
(via sciencedaily.com) Original source Researchers have discovered a mechanism steering the evolution of multicellular life. They identified how altered protein folding drives multicellular evolution.
Published Mutation solves a century-old mystery in meiosis
(via sciencedaily.com) Original source A team deciphers complicated mechanism underlying genetic diversity.
Published Researchers develop artificial building blocks of life
(via sciencedaily.com) Original source For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.
Published Researchers open new leads in anti-HIV drug development, using a compound found in nature
(via sciencedaily.com) Original source A team of researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.
Published Vitamin A may play a central role in stem cell biology and wound repair
(via sciencedaily.com) Original source Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.
Published How does a virus hijack insect sperm to control disease vectors and pests?
(via sciencedaily.com) Original source A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.
Published The Malaria parasite generates genetic diversity using an evolutionary 'copy-paste' tactic
(via sciencedaily.com) Original source All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.
Published First atom-level structure of packaged viral genome reveals new properties, dynamics
(via sciencedaily.com) Original source A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and drug targets researchers report.
Published Cracking epigenetic inheritance: Biologists discovered the secrets of how gene traits are passed on
(via sciencedaily.com) Original source A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.