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Categories: Biology: Biotechnology, Energy: Alternative Fuels

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Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the activation of all available repair mechanisms. A research team has now shown that normal body cells can also be repaired better once this complex has been deactivated. In the long run, the scientists hope to develop better therapies to prevent cancer and aging-associated diseases.

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Scientists have significantly advanced the race to control plant responses to temperature on a rapidly warming planet. Key to this breakthrough is miRNA, a molecule nearly 200,000 times smaller than the width of a human hair.

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Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. Researchers have now described a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans. These effector memory B cells appear to be poised for a rapid serum antibody response upon secondary challenge one year later.

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Researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.

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Renewable energy experts have come up with an environmentally-friendly plan to dispose of solar panels at the end of their life.

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Future ocean warming and marine heatwaves could impact the growth and development of clownfish during their earliest life stages, suggests a new study.

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Natural and engineered versions of tardigrade proteins can be used to stabilize an important pharmaceutical used to treat people with hemophilia and other conditions without the need for refrigeration -- even amid high temperatures and other difficult conditions.

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Sunlight can be used to produce green hydrogen directly from water in photoelectrochemical (PEC) cells. So far, most systems based on this 'direct approach' have not been energetically competitive. However, the balance changes as soon as some of the hydrogen in such PEC cells is used in-situ for a catalytic hydrogenation reaction, resulting in the co-production of chemicals used in the chemical and pharmaceutical industries. The energy payback time of photoelectrochemical 'green' hydrogen production can be reduced dramatically, the study shows.

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Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway. Researchers now characterize how the enzyme PCYT2 affects muscle health in disease and aging in laboratory mouse models.

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The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.

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A new discovery, reported in a global study that encompassed more than a decade of research, could lead to the breeding of corn crops that can withstand drought and low-nitrogen soil conditions and ultimately ease global food insecurity.

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Without plants, we'd have no air to breathe or food to eat, yet plant science lingers in the shadowy wings while other fields take center stage. With the goal of shining the spotlight on plants, a new study presents the field's top 100 most pressing questions for research to address the greatest challenges facing humanity.

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An international research team produced the first large-scale analysis of more than 400 newly sequenced and existing Omnitrophota genomes, uncovering new details about their biology and behavior.

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It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery -- until possibly now. Researchers have found that female mouse and human Natural Killer cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.

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Solar cells made from metal halide perovskites achieve high efficiencies and their production from liquid inks requires only a small amount of energy. Scientists are investigating the production process. At the X-ray source BESSY II, the group has analyzed the optimal composition of precursor inks for the production of high-quality FAPbI3 perovskite thin films by slot-die coating. The solar cells produced with these inks were tested under real life conditions in the field for a year and scaled up to mini-module size.

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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.

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The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways. A new review highlights six mechanisms by which cells repair DNA damage. By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.

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Some projections show that widespread adoption of electric vehicles might require costly new power plants to meet peak loads in the evening. A new study shows that placing EV charging stations strategic ways and setting up systems to initiate charging at delayed times could lessen or eliminate the need for new power plants.