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Categories: Biology: Biochemistry, Chemistry: Biochemistry

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Researchers have uncovered startling connections between micronutrient deficiencies and the composition of gut microbiomes in early life that could help explain why resistance to antibiotics has been rising across the globe. The team investigated how deficiencies in crucial micronutrients such as vitamin A, B12, folate, iron, and zinc affected the community of bacteria, viruses, fungi and other microbes that live in the digestive system. They discovered that these deficiencies led to significant shifts in the gut microbiome of mice -- most notably an alarming expansion of bacteria and fungi known to be opportunistic pathogens. Importantly, mice with micronutrient deficiencies also exhibited a higher enrichment of genes that have been linked to antibiotic resistance.

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Bio-based plastics often end up in recycling streams because they look and feel like conventional plastic, but the contamination of these compostable products makes it much harder to generate functional material out of recycled plastic. Scientists have now developed a biology-driven process to convert these mixtures into a new biodegradable material that can be used to make fresh products. The scientists believe the process could also enable a new field of biomanufacturing wherein valuable chemicals and even medicines are made from microbes feeding off of plastic waste.

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For over 20 years, a research team has studied the common bluetail damselfly. Females occur in three different color forms -- one with a male-like appearance, something that protects them from mating harassment. In a new study, an international research team found that this genetic color variation that is shared between several species arose through changes in a specific genomic region at least five million years ago.

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Old people who follow a Mediterranean diet are at a lower risk of cognitive decline, according to a new study. The study provides new evidence for a better understanding of the biological mechanisms related to the impact of the diet on cognitive health in the aging population.

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Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.

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CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions.   While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.

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In 1973, physicist Phil Anderson hypothesized that the quantum spin liquid, or QSL, state existed on some triangular lattices, but he lacked the tools to delve deeper. Fifty years later, a team has confirmed the presence of QSL behavior in a new material with this structure, KYbSe2.  

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Algae living within the soft tissue of coral supply much of the energy needed by their hosts, and some symbiotic algae help coral withstand warmer water better than others. Researchers have now found that there was a tradeoff for corals dominated by the thermally sensitive algae -- they have higher growth, but only in cooler water.

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Researchers have rediscovered and successfully cultivating Rhabdamoeba marina -- a rare marine amoeba that has only been reported in two cases in the past century. Using this culture strain, they performed a comprehensive analysis of its genetic sequence, revealing for the first time the phylogenetic position of this enigmatic amoeba, and proposed a novel taxonomic classification based on their research findings.

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Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.

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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation.  Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.

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Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.

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A team of pioneering researchers has made a significant leap forward in the complex world of molecular chemistry. Their focus? Azaarenes, unique molecular puzzle pieces crucial to many everyday products, from eco-friendly agrochemicals to essential medicines. The team developed an innovative way to modify these molecules using light-powered enzymes -- a groundbreaking discovery that holds promise for new industrially relevant chemical reactions and sustainable energy solutions.

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New research has revealed that bumblebees cannot taste pesticides present in nectar, even at lethal concentrations. This means bumblebees are not able to avoid contaminated nectar, putting them at high risk of pesticide exposure and posing a threat to crop pollination.

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The internal clocks of grizzly bears appear to keep ticking through hibernation, according to a genetic study. This persistence highlights the strong role of circadian rhythms in the metabolism of many organisms including humans. The genetic study confirmed observational evidence that bears' energy production still waxes and wanes in a daily pattern even as they slumber for several months without eating. The researchers also found that during hibernation the amplitude of the energy production was blunted, meaning the range of highs and lows was reduced. The peak also occurred later in the day under hibernation than during the active season, but the daily fluctuation was still there. 

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Human trade and transport have led to the intentional and accidental introductions of non-native species outside of their natural range globally. These biological invasions can cause extinctions, cost trillions, and spread diseases. A study has investigated how many of these non-native species already exist worldwide and which species groups are particularly prone to become non-native.

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Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.

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Energy researchers posit hydrogen fuel can potentially be a cost-competitive and environmentally friendly alternative to gasoline and diesel, and that supplying hydrogen for transportation in the greater Houston area can be profitable today.

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Many mammals, from domestic cats and dogs to giant pandas, use scent to communicate with each other. A new study shows how domestic cats send signals to each other using odors derived from families of bacteria living in their anal glands. 

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Social distancing when sick has become second nature to many of us in the past few years, but some sick animals appear to take a different approach. A new study of house finches uncovered a surprising result. Unlike other social animals who passively or actively isolate themselves when sick, this gregarious backyard bird species gravitates toward healthy flock mates when they are sick, even more so than healthy birds do.