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Categories: Biology: Biochemistry, Chemistry: Biochemistry

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Many bacterial pathogens use small injection apparatuses to manipulate the cells of their hosts, such as humans, so that they can spread throughout the body. To do this, they need to fill their syringes with the relevant injection agent. A technique that tracks the individual movement of proteins revealed how bacteria accomplish this challenging task.

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A new study to motivate your New Year's resolutions: it demonstrates that high-fat diets negatively impact genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system and brain function.

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Scientific researchers draw inspiration from nature's brilliance as they seek to develop transformative solutions to unresolved challenges.

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For talkative midshipman fish -- sometimes called the 'California singing fish' -- the midbrain plays a robust role in initiating and patterning of sounds used in vocal communication.

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Chemists found a way to use electricity to boost a type of chemical reaction often used in synthesizing new candidates for pharmaceutical drugs. The research is an advance in the field of electrochemistry and shows a path forward to designing and controlling reactions -- and making them more sustainable.

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Scientists develop a new, high-resolution technique for finding potential therapeutic targets on proteins in living cells. The findings could lead to more targeted therapeutics for nearly any human disease.

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Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.

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Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as well as ability to inhibit specific enzymes or target proteins through three-dimensional binding. They also hold promise for swift diagnoses of colon cancer and other challenging diseases by targeting elusive biomarkers. Despite their utility, these aptamers are susceptible to easy degradation by multiple enzymes, presenting a significant challenge.

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Three modules forming a new-to-nature CO2 fixation cycle have been successfully implemented in E.coli.

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Researchers have discovered that molecules experience non-reciprocal interactions without external forces. Fundamental forces such as gravity and electromagnetism are reciprocal, where two objects are attracted to each other or are repelled by each other. In our everyday experience, however, interactions don t seem to follow this reciprocal law.

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A research team has unveiled a remarkable breakthrough in cancer treatment.

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Barley seedlings grow on average 50% more when their root system is stimulated electrically through a new cultivation substrate. Researchers have now developed an electrically conductive 'soil' for soil-less cultivation, known as hydroponics.

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Study findings raise the stakes for public health efforts to improve attitudes about vaccination rates across the board.

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Researchers report that the more time reindeer spend ruminating, the less time they spend in non-rapid eye movement (non-REM) sleep. EEG recordings revealed that reindeer's brainwaves during rumination resemble the brain waves present during non-REM sleep, and these brainwave patterns suggest that the reindeer are more 'rested' after ruminating. The researchers speculate that this multitasking might help reindeer get enough sleep during the summer months, when food is abundant and reindeer feed almost 24/7 in preparation for the long and food-sparse arctic winter.

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Researchers found that a Transient Receptor Potential (TRP) A1 stimulant, 2-methylthiazoline (2MT), act as a potent insect repellent in Drosophila. 2MT induces aversive behaviors via olfactory, gustatory, and nociceptive sensory pathways. 2MT acts on TRPA1 through specific cysteine residues that are conserved across many insect pest species.

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Tiny things matter -- for instance, one amino acid can completely alter the architecture of the cell. Researchers have now investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has a range of important functions -- from muscle contraction to cell signalling and cell shape. This protein comes in two different varieties termed 'isoforms', which are known as gamma actin and beta actin.

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At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.

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A lot has changed in the world since the Endangered Species Act (ESA) was enacted 50 years ago in December 1973. Experts are now discuss how the ESA has evolved and what its future might hold. 

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Researchers mapped how the measles virus mutated and spread in the brain of a person who succumbed to a rare, lethal brain disease. New cases of this disease, which is a complication of the measles virus, may occur as measles reemerges among the unvaccinated, say researchers.

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Scientists reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands.