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Categories: Biology: Biochemistry, Mathematics: Modeling
Published Researchers open new leads in anti-HIV drug development, using a compound found in nature
(via sciencedaily.com) Original source A team of researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.
Published Balancing training data and human knowledge makes AI act more like a scientist
(via sciencedaily.com) Original source When you teach a child how to solve puzzles, you can either let them figure it out through trial and error, or you can guide them with some basic rules and tips. Similarly, incorporating rules and tips into AI training -- such as the laws of physics --could make them more efficient and more reflective of the real world. However, helping the AI assess the value of different rules can be a tricky task.
Published Reptile roadkill reveals new threat to endangered lizard species
(via sciencedaily.com) Original source The chance sighting of a dead snake beside a sandy track in remote Western Australia, and the investigation of its stomach contents, has led researchers to record the first known instance of a spotted mulga snake consuming a pygmy spiny-tailed skink, raising concerns for a similar-looking, endangered lizard species.
Published The role of machine learning and computer vision in Imageomics
(via sciencedaily.com) Original source A new field promises to usher in a new era of using machine learning and computer vision to tackle small and large-scale questions about the biology of organisms around the globe.
Published New technique may help scientists stave off coral reef collapse
(via sciencedaily.com) Original source Producing coral skeleton components in the easy-to-use soft-bodied sea anemone Nematostella creates a perfect lab system for studying, and eventually helping, corals threatened by a changing climate.
Published Vitamin A may play a central role in stem cell biology and wound repair
(via sciencedaily.com) Original source Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.
Published How does a virus hijack insect sperm to control disease vectors and pests?
(via sciencedaily.com) Original source A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.
Published The Malaria parasite generates genetic diversity using an evolutionary 'copy-paste' tactic
(via sciencedaily.com) Original source All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.
Published First atom-level structure of packaged viral genome reveals new properties, dynamics
(via sciencedaily.com) Original source A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and drug targets researchers report.
Published Method rapidly verifies that a robot will avoid collisions
(via sciencedaily.com) Original source A new safety-check technique can prove with 100 percent accuracy that a planned robot motion will not result in a collision. The method can generate a proof in seconds and does so in a way that can be easily verified by a human.
Published Cracking epigenetic inheritance: Biologists discovered the secrets of how gene traits are passed on
(via sciencedaily.com) Original source A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.
Published What makes a pathogen antibiotic-resistant?
(via sciencedaily.com) Original source In a comparative study, researchers describe how two notable pathogens -- Escherichia coli and Acinetobacter baumannii -- employ distinctly different tools to fend off antibiotic attack by two different drugs.
Published The sweet stuff: How insects tell sugars apart
(via sciencedaily.com) Original source Whereas humans have one receptor on their tongues that can detect all sorts of sweet things, from real sugar to artificial sweeteners like aspartame, insects have many receptors that each detect specific types of sugars. Researchers have now uncovered one way insect receptors are able to be so selective, an insight they say will help us understand how animals decipher the chemical world and how we might mimic that ability in the future.
Published Revealing a hidden threat: Researchers show viral infections pose early heart risks
(via sciencedaily.com) Original source In a potentially game-changing development, scientists have revealed a new understanding of sometimes fatal viral infections that affect the heart. Traditionally, the focus has been on heart inflammation known as myocarditis, which is often triggered by the body's immune response to a viral infection. However, a new study sheds new light on this notion, revealing that the virus itself creates potentially dangerous conditions in the heart before inflammation sets in.
Published Microbes impact coral bleaching susceptibility
(via sciencedaily.com) Original source A new study provides insights into the role of microbes and their interaction as drivers of interspecific differences in coral thermal bleaching.
Published Early life adversity leaves long-term signatures in baboon DNA
(via sciencedaily.com) Original source Early experiences in an animal's life can have a significant impact on its capacity to thrive, even years or decades later, and DNA methylation may help record their effects. In a study of 256 wild baboons, researchers found that resource limitation during early life was associated with many differences in DNA methylation, a small chemical mark on the DNA sequence that can affect gene activity.
Published First heat map for individual red blood cells
(via sciencedaily.com) Original source Entropy is often associated with disorder and chaos, but in biology it is related to energy efficiency and is closely linked to metabolism, the set of chemical reactions that sustain life. An international research team has now developed a novel methodology for the measurement of entropy production at the scale of a nanometer, meaning one-billionth of a meter. The new approach enabled the scientists to measure the heat flow, known as the entropy production rate, of single red blood cells.
Published The world's most prolific CO2-fixing enzyme is slowly getting better
(via sciencedaily.com) Original source New research has found that rubisco -- the enzyme that fuels all life on Earth -- is not stuck in an evolutionary rut after all. The largest analysis of rubisco ever has found that it is improving all the time -- just very, very slowly. These insights could potentially open up new routes to strengthen food security.
Published Marine algae implants could boost crop yields
(via sciencedaily.com) Original source Scientists have discovered the gene that enables marine algae to make a unique type of chlorophyll. They successfully implanted this gene in a land plant, paving the way for better crop yields on less land.
Published Global warming is affecting bats' hibernation
(via sciencedaily.com) Original source Global change is altering the physiology of the hibernation and behavior of bats, according to a study carried out over a twenty year period. Given the milder winters we are having, bats are accumulating less fat reserves in autumn, they shorten their hibernation periods and they leave their winter shelter sooner. These changes could alter the migration pattern of bats and the phenology of their seasonal displacements.