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Categories: Biology: Biochemistry, Engineering: Graphene
Published A more effective experimental design for engineering a cell into a new state
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A new machine-learning approach helps scientists more efficiently identify the optimal intervention to achieve a certain outcome in a complex system, such as genome regulation, requiring far fewer experimental trials than other methods.Â
Published Researchers studied thousands of fertility attempts hoping to improve IVF
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By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.
Published Edges cause cilia to quickly synchronize their beating pattern
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Border regions can cause cilia to coordinate their motion creating a unidirectional wave that is essential for biological functions. Scientists proposed a new model describing this synchronized pattern driven by the border region.
Published Small but mighty new gene editor
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A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders. The tool is an enzyme, AsCas12f, which has been modified to offer the same effectiveness but at one-third the size of the Cas9 enzyme commonly used for gene editing. The compact size means that more of it can be packed into carrier viruses and delivered into living cells, making it more efficient.
Published Genome study reveals 30 years of Darwin's finch evolution
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An international team of researchers has released a landmark study on contemporary evolutionary change in natural populations. Their study uses one of the largest genomic datasets ever produced for animals in their natural environment, comprising nearly 4,000 Darwin's finches. The study has revealed the genetic basis of adaptation in this iconic group.
Published Allergy study on 'wild' mice challenges the hygiene hypothesis
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The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis. Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.
Published Gut inflammation caused by substance secreted by microbe
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A rare subtype of the world's most common parasite, Blastocystis, has been found to produce a unique by-product of its metabolism, which can cause gut inflammation under normal gut conditions.
Published Insights into early snake evolution through brain analysis
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Recent study sheds new light on the enigmatic early evolution of snakes by examining an unexpected source: their brains. The results emphasize the significance of studying both the soft parts of animals’ bodies and their bones for understanding how animals evolved.
Published Explosion in fish biodiversity due to genetic recycling
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The rapid formation of 500 different species of fish in a single lake, each with specialized ecological roles, resulted from a small but genetically diverse hybrid population.
Published Timing plant evolution with a fast-ticking epigenetic clock
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Recent discoveries in the field of epigenetics, the study of inheritance of traits that occur without changing the DNA sequence, have shown that chronological age in mammals correlates with epigenetic changes that accumulate during the lifetime of an individual. In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. While these clocks work accurately from birth until death, they are set back to zero in each new generation. Now, an international team shows that epigenetic clocks not only exist in plants, but that these clocks keep ticking accurately over many generations.
Published Skin behind the ears and between the toes can host a collection of unhealthy microbes
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Scrubbing behind the ears and between the toes may help keep the skin in those regions healthy, new research suggests. The microbiome, or the collection of microbes living on and in the human body, are known to play a role in human health and the skin is no different. A new study has shown that the composition of the skin microbiome varies across dry, moist and oily regions of the skin.
Published Solving a sticky, life-threatening problem
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Researchers have zeroed in on C. auris' uncanny ability to stick to everything from skin to catheters and made a startling discovery: it uses a protein similar to that used by barnacles and mollusks.
Published Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered
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Scientists have identified the source of antibiotic resistance that emerged within bacteria driving the ongoing Yemen cholera epidemic.
Published Did animal evolution begin with a predatory lifestyle?
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Surprising findings on the development of sea anemones suggest that a predatory lifestyle molded their evolution and had a significant impact on the origin of their nervous system. The researchers were able to show that the young life stages (larvae) of the small sea anemone Aiptasia actively feed on living prey and are not dependent on algae. To capture its prey, the anemone larvae use specialized stinging cells and a simple neuronal network.
Published A lethal parasite's secret weapon: Infecting non-immune cells
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The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Published Malaria: Treatment of Plasmodium falciparum malaria patients under threat in the Horn of Africa
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Diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests and treatment with artemisinin derivatives, the main component of the malaria treatments recommended by the World Health Organization (WHO), are under threat in the Horn of Africa. Scientists have detected the emergence and spread in Eritrea of parasites with both artemisinin resistance and genome modifications that prevent their detection with rapid diagnostic tests, thereby jeopardizing malaria control and elimination campaigns in the region and potentially elsewhere in Africa.
Published Polyps as pixels: Innovative technique maps biochemistry of coral reefs
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Using an innovative new approach to sampling corals, researchers are now able to create maps of coral biochemistry that reveal with unprecedented detail the distribution of compounds that are integral to the healthy functioning of reefs.
Published An advance in cryo-EM could be a significant boon for research on potential cancer therapies
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A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules. A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of such molecules. The advance is significant because small and medium-sized protein molecules are an area of focus in research on potential new drugs for cancer and other diseases.
Published Researchers dynamically tune friction in graphene
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The friction on a graphene surface can be dynamically tuned using external electric fields, according to researchers.
Published Fish reveal cause of altered human facial development
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Some substances in medicines, household items and the environment are known to affect prenatal child development. Researchers tested the effects of five drugs (including caffeine and the blood thinner warfarin) on the growth of zebrafish embryos. They found that all five had the same effect, impairing the migration of bone-forming cells which resulted in the onset of facial malformation. Zebrafish embryos grow quickly, are transparent and develop outside of the parent's body, making them ideal for studying early development. A zebrafish-based system could be used to easily screen for potentially harmful substances, reducing animal testing on mammals and supporting parents-to-be when making choices for themselves and their baby.