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Categories: Chemistry: Organic Chemistry

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Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, making it important to have methods that can selectively detect active proteases. Scientists have introduced a new class of protease-activity sensors: gold nanoparticles equipped with peptide DNA.

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In mice and human cell cultures, researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer's disease.

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Antibodies hold promise as therapeutic agents. However, their tendency to aggregate poses significant challenges to drug development. In a groundbreaking study, researchers now provide novel insights into the structure formed due to 3D domain swapping of the antibody light chain, the part of the antibody contributing to antigen binding. Their findings are expected to lead to improvements in antibody quality and the development of novel drugs.

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After more than a decade of developing fluorescent probes, a research team has now released the culmination of their years of work: A comprehensive collection of rhodamine-based dyes, the novel chemistry they developed to synthesize them and insights that provide a roadmap for designing future probes.

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Chemists have now come up with a way to make molecules known as acenes more stable, allowing them to synthesize acenes of varying lengths. Using their new approach, they were able to build molecules that emit red, orange, yellow, green, or blue light, which could make acenes easier to deploy in a variety of applications.

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Researchers have uncovered the intricate molecular mechanism used by parasitic phytoplasma bacteria, known for inducing 'zombie-like' effects in plants.

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Scientists have made a significant stride toward understanding a viable process for direct air capture, or DAC, of carbon dioxide from the atmosphere. This DAC process is in early development with the aim of achieving negative emissions, where the amount of carbon dioxide removed from the envelope of gases surrounding Earth exceeds the amount emitted.

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Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.

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A team presents a groundbreaking advance for the world of high-resolution fluorescence microscopy: The innovative method enables researchers for the first time to use biomolecules as molecular rulers to calibrate the latest super-resolution microscopy methods, which have a resolution of just a few nanometers.

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A collaborative research team has discovered a new process for making anhydrides that promises improvements in costs and sustainability.

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Researchers have developed an AI model that can predict where a drug molecule can be chemically altered.

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Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

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Used lithium-ion batteries from cell phones, laptops and a growing number of electric vehicles are piling up, but options for recycling them remain limited mostly to burning or chemically dissolving shredded batteries. Researchers have improved on approaches that dissolve the battery in a liquid solution in order to reduce the amount of hazardous chemicals used in the process. This simple, efficient and environmentally-friendly solution overcomes the main obstacles presented by previous approaches.

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Researchers have devised a way to produce chemicals used in medicine and agriculture for a fraction of the usual cost. Using oxygen as a reagent and copper as a catalyst to break organic molecules' carbon-carbon bonds and convert them into amines, which are widely used in pharmaceuticals. Traditional metal catalysis uses expensive metals such as platinum, silver, gold and palladium, but the researchers used oxygen and copper -- an abundant base metal.

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Researchers have developed a new method for the accurate determination of the water content of water-soluble compounds. This plays a significant role in various areas, including determining drug dosages.

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Global measurements and model calculations show that the complex relationship between the chemistry and climate impact of aerosol particles can be successfully captured by a simple formula.

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Bio-based plastics often end up in recycling streams because they look and feel like conventional plastic, but the contamination of these compostable products makes it much harder to generate functional material out of recycled plastic. Scientists have now developed a biology-driven process to convert these mixtures into a new biodegradable material that can be used to make fresh products. The scientists believe the process could also enable a new field of biomanufacturing wherein valuable chemicals and even medicines are made from microbes feeding off of plastic waste.

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The remarkable proton and oxide-ion (dual-ion) conductivities of hexagonal perovskite-related oxide Ba7Nb3.8Mo1.2O20.1 are promising for next-generation electrochemical devices. The unique ion-transport mechanisms they unveiled will hopefully pave the way for better dual-ion conductors, which could play an essential role in tomorrow's clean energy technologies.

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A team of pioneering researchers has made a significant leap forward in the complex world of molecular chemistry. Their focus? Azaarenes, unique molecular puzzle pieces crucial to many everyday products, from eco-friendly agrochemicals to essential medicines. The team developed an innovative way to modify these molecules using light-powered enzymes -- a groundbreaking discovery that holds promise for new industrially relevant chemical reactions and sustainable energy solutions.

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Protein cages found in nature within microbes help weather its contents from the harsh intracellular environment -- an observation with many bioengineering applications. Researchers recently developed an innovative bioengineering approach using genetically modified bacteria; these bacteria can incorporate protein cages around protein crystals. This in-cell biosynthesis method efficiently produces highly customized protein complexes, which could find applications as advanced solid catalysts and functionalized nanomaterials.